Two cases of childhood linear immunoglobulin A bullous dermatosis following multivisceral transplant: A case report

Childhood linear immunoglobulin A bullous dermatosis is a well-recognized autoimmune blistering dermatosis that can be idiopathic, drug-induced, secondary to autoimmune diseases, malignancies, infections, or gastrointestinal diseases including inflammatory bowel disease. However, it has not been pre...

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Main Authors: Adam C Yu, Airiss R Chan, Kerry Wong, Kirsten Walker, Loretta Fiorillo
Format: Article
Language:English
Published: SAGE Publishing 2024-12-01
Series:SAGE Open Medical Case Reports
Online Access:https://doi.org/10.1177/2050313X241304956
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author Adam C Yu
Airiss R Chan
Kerry Wong
Kirsten Walker
Loretta Fiorillo
author_facet Adam C Yu
Airiss R Chan
Kerry Wong
Kirsten Walker
Loretta Fiorillo
author_sort Adam C Yu
collection DOAJ
description Childhood linear immunoglobulin A bullous dermatosis is a well-recognized autoimmune blistering dermatosis that can be idiopathic, drug-induced, secondary to autoimmune diseases, malignancies, infections, or gastrointestinal diseases including inflammatory bowel disease. However, it has not been previously associated with a history of organ transplantation. Here, we report two cases of childhood linear immunoglobulin A bullous dermatosis in young infants following multivisceral organ transplant, including one with a particularly recalcitrant course. We propose potential mechanisms contributing to the development of linear immunoglobulin A bullous dermatosis and challenges in the management of these patients in light of their complex medical histories and immunosuppression.
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institution Kabale University
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publisher SAGE Publishing
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series SAGE Open Medical Case Reports
spelling doaj-art-c4d29e6ecec640baa269b2ea1af499da2024-12-24T14:03:51ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2024-12-011210.1177/2050313X241304956Two cases of childhood linear immunoglobulin A bullous dermatosis following multivisceral transplant: A case reportAdam C Yu0Airiss R Chan1Kerry Wong2Kirsten Walker3Loretta Fiorillo4Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, CanadaDivision of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, CanadaDivision of Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, AB, CanadaDivision of Dermatology, University of Saskatchewan, Saskatoon, SK, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, AB, CanadaChildhood linear immunoglobulin A bullous dermatosis is a well-recognized autoimmune blistering dermatosis that can be idiopathic, drug-induced, secondary to autoimmune diseases, malignancies, infections, or gastrointestinal diseases including inflammatory bowel disease. However, it has not been previously associated with a history of organ transplantation. Here, we report two cases of childhood linear immunoglobulin A bullous dermatosis in young infants following multivisceral organ transplant, including one with a particularly recalcitrant course. We propose potential mechanisms contributing to the development of linear immunoglobulin A bullous dermatosis and challenges in the management of these patients in light of their complex medical histories and immunosuppression.https://doi.org/10.1177/2050313X241304956
spellingShingle Adam C Yu
Airiss R Chan
Kerry Wong
Kirsten Walker
Loretta Fiorillo
Two cases of childhood linear immunoglobulin A bullous dermatosis following multivisceral transplant: A case report
SAGE Open Medical Case Reports
title Two cases of childhood linear immunoglobulin A bullous dermatosis following multivisceral transplant: A case report
title_full Two cases of childhood linear immunoglobulin A bullous dermatosis following multivisceral transplant: A case report
title_fullStr Two cases of childhood linear immunoglobulin A bullous dermatosis following multivisceral transplant: A case report
title_full_unstemmed Two cases of childhood linear immunoglobulin A bullous dermatosis following multivisceral transplant: A case report
title_short Two cases of childhood linear immunoglobulin A bullous dermatosis following multivisceral transplant: A case report
title_sort two cases of childhood linear immunoglobulin a bullous dermatosis following multivisceral transplant a case report
url https://doi.org/10.1177/2050313X241304956
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