Deep brain stimulation of Hippocampus in Treatment-resistant Schizophrenia (DBS-HITS): protocol for a crossover randomized controlled trial

Deep brain stimulation of Hippocampus in Treatment-resistant Schizophrenia (DBS-HITS): protocol for a crossover randomized controlled trial

Abstract Background Ventral hippocampus (vHipp) in schizophrenia is in a state of hyperactivity and hypermetabolism, where the glutamate/gamma-aminobutyric acid (GABA) imbalance leads to downstream dopamine hyperactivity in the midbrain-limbic system. High-frequency deep brain stimulation (DBS) can...

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Bibliographic Details
Main Authors: Chang Lu, Zhaolin Zhai, Kaiming Zhuo, Qiong Xiang, Jingxin Xue, Yuqing Zhao, Liqin Lang, Chunhong Shao, Liang Chen, Dengtang Liu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Psychiatry
Subjects:
Deep brain stimulation (DBS)
Hippocampus
Treatment-resistant schizophrenia (TRS)
Randomized controlled trial (RCT)
Study protocol
Online Access:https://doi.org/10.1186/s12888-024-06318-6
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