Fluoride induces hepatointestinal damage and vitamin B2 mitigation by regulating IL-17A and Bifidobacterium in ileum

Fluoride induces hepatointestinal damage and vitamin B2 mitigation by regulating IL-17A and Bifidobacterium in ileum

Introduction: Fluorosis is a global public health disease affecting more than 50 countries and 500 million people. Excessive fluoride damages the liver and intestines, yet the mechanisms and therapeutic approaches remain unclear. Objectives: To explore the mechanisms by which fluoride-induced intest...

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Main Authors: Chen Liang, Cuicui Zhuang, Chenkai Cheng, Jian Bai, Yue Wu, Xiang Li, Jie Yang, Bohui Li, Weixiang Fu, Qianlong Zhu, Jiawei Lv, Yanjia Tan, Ram Kumar Manthari, Yangfei Zhao, Jundong Wang, Jianhai Zhang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Advanced Research
Subjects:
Fluoride
Vitamin B2
Enterohepatic circulation
IL-17A
Ileal microbiome
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003175
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