Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy
Abstract Peripheral neuropathy (PN), the most common complication of diabetes, leads to sensory loss and associated health issues as pain and increased fall risk. However, present treatments do not counteract sensory loss, but only partially manage its consequences. Electrical neural stimulation hol...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55152-7 |
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| author | Noemi Gozzi Lauren Chee Ingrid Odermatt Sanne Kikkert Greta Preatoni Giacomo Valle Nikolai Pfender Felix Beuschlein Nicole Wenderoth Carl Zipser Stanisa Raspopovic |
| author_facet | Noemi Gozzi Lauren Chee Ingrid Odermatt Sanne Kikkert Greta Preatoni Giacomo Valle Nikolai Pfender Felix Beuschlein Nicole Wenderoth Carl Zipser Stanisa Raspopovic |
| author_sort | Noemi Gozzi |
| collection | DOAJ |
| description | Abstract Peripheral neuropathy (PN), the most common complication of diabetes, leads to sensory loss and associated health issues as pain and increased fall risk. However, present treatments do not counteract sensory loss, but only partially manage its consequences. Electrical neural stimulation holds promise to restore sensations, but its efficacy and benefits in PN damaged nerves are yet unknown. We designed a wearable sensory neuroprosthesis (NeuroStep) providing targeted neurostimulation of the undamaged nerve portion and assessed its functionality in 14 PN participants. Our system partially restored lost sensations in all participants through a purposely calibrated neurostimulation, despite PN nerves being less sensitive than healthy nerves (N = 22). Participants improved cadence and functional gait and reported a decrease of neuropathic pain after one day. Restored sensations activated cortical patterns resembling naturally located foot sensations. NeuroStep restores real-time intuitive sensations in PN participants, holding potential to enhance functional and health outcomes while advancing effective non-invasive neuromodulation. |
| format | Article |
| id | doaj-art-c4acbf400d844a3f8c723e1835ee1876 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-c4acbf400d844a3f8c723e1835ee18762025-01-05T12:35:45ZengNature PortfolioNature Communications2041-17232024-12-0115111910.1038/s41467-024-55152-7Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathyNoemi Gozzi0Lauren Chee1Ingrid Odermatt2Sanne Kikkert3Greta Preatoni4Giacomo Valle5Nikolai Pfender6Felix Beuschlein7Nicole Wenderoth8Carl Zipser9Stanisa Raspopovic10Neuroengineering Laboratory, Department of Health Sciences and Technology, ETH ZurichNeuroengineering Laboratory, Department of Health Sciences and Technology, ETH ZurichNeural Control of Movement Lab, Department of Health Sciences and Technology, ETH ZurichNeural Control of Movement Lab, Department of Health Sciences and Technology, ETH ZurichNeuroengineering Laboratory, Department of Health Sciences and Technology, ETH ZurichNeuroengineering Laboratory, Department of Health Sciences and Technology, ETH ZurichDepartment of Neurology and Neurophysiology, Balgrist University HospitalDepartment of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH)Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH ZurichDepartment of Neurology and Neurophysiology, Balgrist University HospitalNeuroengineering Laboratory, Department of Health Sciences and Technology, ETH ZurichAbstract Peripheral neuropathy (PN), the most common complication of diabetes, leads to sensory loss and associated health issues as pain and increased fall risk. However, present treatments do not counteract sensory loss, but only partially manage its consequences. Electrical neural stimulation holds promise to restore sensations, but its efficacy and benefits in PN damaged nerves are yet unknown. We designed a wearable sensory neuroprosthesis (NeuroStep) providing targeted neurostimulation of the undamaged nerve portion and assessed its functionality in 14 PN participants. Our system partially restored lost sensations in all participants through a purposely calibrated neurostimulation, despite PN nerves being less sensitive than healthy nerves (N = 22). Participants improved cadence and functional gait and reported a decrease of neuropathic pain after one day. Restored sensations activated cortical patterns resembling naturally located foot sensations. NeuroStep restores real-time intuitive sensations in PN participants, holding potential to enhance functional and health outcomes while advancing effective non-invasive neuromodulation.https://doi.org/10.1038/s41467-024-55152-7 |
| spellingShingle | Noemi Gozzi Lauren Chee Ingrid Odermatt Sanne Kikkert Greta Preatoni Giacomo Valle Nikolai Pfender Felix Beuschlein Nicole Wenderoth Carl Zipser Stanisa Raspopovic Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy Nature Communications |
| title | Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy |
| title_full | Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy |
| title_fullStr | Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy |
| title_full_unstemmed | Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy |
| title_short | Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy |
| title_sort | wearable non invasive neuroprosthesis for targeted sensory restoration in neuropathy |
| url | https://doi.org/10.1038/s41467-024-55152-7 |
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