Case report: Generalized granuloma annulare successfully treated with baricitinib in two cases
Treatments are challenging in generalized granuloma annulare. We reported two cases of generalized granuloma annulare without diabetes mellitus; one exhibited non-annular papules and the other did patch/annular lesions. Since they were refractory to multiple treatments, we treated them with JAK inhi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Journal of Cutaneous Immunology and Allergy |
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| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/jcia.2024.13892/full |
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| author | Marina Yunoki Shumpei Kondo Masaki Otsuka Yoshiki Tokura Yoshiki Tokura |
| author_facet | Marina Yunoki Shumpei Kondo Masaki Otsuka Yoshiki Tokura Yoshiki Tokura |
| author_sort | Marina Yunoki |
| collection | DOAJ |
| description | Treatments are challenging in generalized granuloma annulare. We reported two cases of generalized granuloma annulare without diabetes mellitus; one exhibited non-annular papules and the other did patch/annular lesions. Since they were refractory to multiple treatments, we treated them with JAK inhibitor baricitinib at 2 mg daily. After 1–2-month treatment, they responded well to baricitinib with good tolerance. Given increased JAK1 signaling, high interferon-α and -γ production and macrophage activation in granuloma annulare, JAK inhibitors are considered to be a reasonable choice for recalcitrant generalized granuloma annulare. In addition to the reported cases, our two cases further support the effectiveness of JAK inhibitors for generalized granuloma annulare. |
| format | Article |
| id | doaj-art-c4a33c35d816419893ebbe0fa2049418 |
| institution | Kabale University |
| issn | 2574-4593 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Cutaneous Immunology and Allergy |
| spelling | doaj-art-c4a33c35d816419893ebbe0fa20494182025-01-06T04:11:46ZengFrontiers Media S.A.Journal of Cutaneous Immunology and Allergy2574-45932025-01-01710.3389/jcia.2024.1389213892Case report: Generalized granuloma annulare successfully treated with baricitinib in two casesMarina Yunoki0Shumpei Kondo1Masaki Otsuka2Yoshiki Tokura3Yoshiki Tokura4Department of Dermatology and Skin Oncology, Chutoen General Medical Center, Kakegawa, JapanDepartment of Dermatology and Skin Oncology, Chutoen General Medical Center, Kakegawa, JapanDepartment of Dermatology and Skin Oncology, Chutoen General Medical Center, Kakegawa, JapanDepartment of Dermatology and Skin Oncology, Chutoen General Medical Center, Kakegawa, JapanAllergic Disease Research Center, Chutoen General Medical Center, Kakegawa, JapanTreatments are challenging in generalized granuloma annulare. We reported two cases of generalized granuloma annulare without diabetes mellitus; one exhibited non-annular papules and the other did patch/annular lesions. Since they were refractory to multiple treatments, we treated them with JAK inhibitor baricitinib at 2 mg daily. After 1–2-month treatment, they responded well to baricitinib with good tolerance. Given increased JAK1 signaling, high interferon-α and -γ production and macrophage activation in granuloma annulare, JAK inhibitors are considered to be a reasonable choice for recalcitrant generalized granuloma annulare. In addition to the reported cases, our two cases further support the effectiveness of JAK inhibitors for generalized granuloma annulare.https://www.frontierspartnerships.org/articles/10.3389/jcia.2024.13892/fullbaricitinibgranuloma annulareJAK inhibitorupadacitinibabrocitinib |
| spellingShingle | Marina Yunoki Shumpei Kondo Masaki Otsuka Yoshiki Tokura Yoshiki Tokura Case report: Generalized granuloma annulare successfully treated with baricitinib in two cases Journal of Cutaneous Immunology and Allergy baricitinib granuloma annulare JAK inhibitor upadacitinib abrocitinib |
| title | Case report: Generalized granuloma annulare successfully treated with baricitinib in two cases |
| title_full | Case report: Generalized granuloma annulare successfully treated with baricitinib in two cases |
| title_fullStr | Case report: Generalized granuloma annulare successfully treated with baricitinib in two cases |
| title_full_unstemmed | Case report: Generalized granuloma annulare successfully treated with baricitinib in two cases |
| title_short | Case report: Generalized granuloma annulare successfully treated with baricitinib in two cases |
| title_sort | case report generalized granuloma annulare successfully treated with baricitinib in two cases |
| topic | baricitinib granuloma annulare JAK inhibitor upadacitinib abrocitinib |
| url | https://www.frontierspartnerships.org/articles/10.3389/jcia.2024.13892/full |
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