The anti-inflammatory mechanism of acerola based on LPS-induced RAW264.7 macrophages and xylene-induced ear edema in mouse
Acerola cherry has been acknowledged as the best source of natural vitamin C supplements, while the anti-inflammatory effect of acerola (ACC) is still unclear. Component analysis showed that the contents of vitamin C and flavonoids reached 18 % and 2.98 %, respectively. To explore the potential mech...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462400642X |
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| author | Hua Wu Liuping Fan Qun Yu Yanqing Li Ling Tong Cuifeng Cao |
| author_facet | Hua Wu Liuping Fan Qun Yu Yanqing Li Ling Tong Cuifeng Cao |
| author_sort | Hua Wu |
| collection | DOAJ |
| description | Acerola cherry has been acknowledged as the best source of natural vitamin C supplements, while the anti-inflammatory effect of acerola (ACC) is still unclear. Component analysis showed that the contents of vitamin C and flavonoids reached 18 % and 2.98 %, respectively. To explore the potential mechanism of ACC on LPS-induced RAW264.7 inflammation, the expression of proinflammatory cytokines and protein were assessed. ACC inhibited the activation of the iNOS, NF-κB, JAK-STAT3 and MAPK pathways, thus reducing the levels of NO, TNF-α, IL-1β and IL-6. Additionally, ACC exhibited better anti-inflammatory activity than Vc alone. Vc and flavonoids in ACC inhibited xylene-induced ear edema via hindering the generation of TNF-α, IL-1β and inflammatory mediator PGE2. Middle and high doses of Vc and flavonoids were beneficial to alleviate ear inflammation in mice. Significantly, the ear weight and thickness variation were only 16.16 % and 14.91 % under ACC administration, which were the lowest. |
| format | Article |
| id | doaj-art-c4935d1ce77d41d0a7e5e9878d04e5b1 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-c4935d1ce77d41d0a7e5e9878d04e5b12025-01-12T05:24:45ZengElsevierJournal of Functional Foods1756-46462025-01-01124106639The anti-inflammatory mechanism of acerola based on LPS-induced RAW264.7 macrophages and xylene-induced ear edema in mouseHua Wu0Liuping Fan1Qun Yu2Yanqing Li3Ling Tong4Cuifeng Cao5State Key laboratory of Food Science & Resources, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, ChinaState Key laboratory of Food Science & Resources, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, ChinaState Key laboratory of Food Science & Resources, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China; Corresponding author at: Associate professor of School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.Yangshengtang Pharmaceutical Co., Ltd., 148 Shuguang Road, Hangzhou, Zhejiang 310063, ChinaYangshengtang Pharmaceutical Co., Ltd., 148 Shuguang Road, Hangzhou, Zhejiang 310063, ChinaYangshengtang Pharmaceutical Co., Ltd., 148 Shuguang Road, Hangzhou, Zhejiang 310063, ChinaAcerola cherry has been acknowledged as the best source of natural vitamin C supplements, while the anti-inflammatory effect of acerola (ACC) is still unclear. Component analysis showed that the contents of vitamin C and flavonoids reached 18 % and 2.98 %, respectively. To explore the potential mechanism of ACC on LPS-induced RAW264.7 inflammation, the expression of proinflammatory cytokines and protein were assessed. ACC inhibited the activation of the iNOS, NF-κB, JAK-STAT3 and MAPK pathways, thus reducing the levels of NO, TNF-α, IL-1β and IL-6. Additionally, ACC exhibited better anti-inflammatory activity than Vc alone. Vc and flavonoids in ACC inhibited xylene-induced ear edema via hindering the generation of TNF-α, IL-1β and inflammatory mediator PGE2. Middle and high doses of Vc and flavonoids were beneficial to alleviate ear inflammation in mice. Significantly, the ear weight and thickness variation were only 16.16 % and 14.91 % under ACC administration, which were the lowest.http://www.sciencedirect.com/science/article/pii/S175646462400642XAcerolaAnti-inflammatoryRAW264.7 macrophagesEar edema |
| spellingShingle | Hua Wu Liuping Fan Qun Yu Yanqing Li Ling Tong Cuifeng Cao The anti-inflammatory mechanism of acerola based on LPS-induced RAW264.7 macrophages and xylene-induced ear edema in mouse Journal of Functional Foods Acerola Anti-inflammatory RAW264.7 macrophages Ear edema |
| title | The anti-inflammatory mechanism of acerola based on LPS-induced RAW264.7 macrophages and xylene-induced ear edema in mouse |
| title_full | The anti-inflammatory mechanism of acerola based on LPS-induced RAW264.7 macrophages and xylene-induced ear edema in mouse |
| title_fullStr | The anti-inflammatory mechanism of acerola based on LPS-induced RAW264.7 macrophages and xylene-induced ear edema in mouse |
| title_full_unstemmed | The anti-inflammatory mechanism of acerola based on LPS-induced RAW264.7 macrophages and xylene-induced ear edema in mouse |
| title_short | The anti-inflammatory mechanism of acerola based on LPS-induced RAW264.7 macrophages and xylene-induced ear edema in mouse |
| title_sort | anti inflammatory mechanism of acerola based on lps induced raw264 7 macrophages and xylene induced ear edema in mouse |
| topic | Acerola Anti-inflammatory RAW264.7 macrophages Ear edema |
| url | http://www.sciencedirect.com/science/article/pii/S175646462400642X |
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