The anti-inflammatory mechanism of acerola based on LPS-induced RAW264.7 macrophages and xylene-induced ear edema in mouse
Acerola cherry has been acknowledged as the best source of natural vitamin C supplements, while the anti-inflammatory effect of acerola (ACC) is still unclear. Component analysis showed that the contents of vitamin C and flavonoids reached 18 % and 2.98 %, respectively. To explore the potential mech...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462400642X |
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| Summary: | Acerola cherry has been acknowledged as the best source of natural vitamin C supplements, while the anti-inflammatory effect of acerola (ACC) is still unclear. Component analysis showed that the contents of vitamin C and flavonoids reached 18 % and 2.98 %, respectively. To explore the potential mechanism of ACC on LPS-induced RAW264.7 inflammation, the expression of proinflammatory cytokines and protein were assessed. ACC inhibited the activation of the iNOS, NF-κB, JAK-STAT3 and MAPK pathways, thus reducing the levels of NO, TNF-α, IL-1β and IL-6. Additionally, ACC exhibited better anti-inflammatory activity than Vc alone. Vc and flavonoids in ACC inhibited xylene-induced ear edema via hindering the generation of TNF-α, IL-1β and inflammatory mediator PGE2. Middle and high doses of Vc and flavonoids were beneficial to alleviate ear inflammation in mice. Significantly, the ear weight and thickness variation were only 16.16 % and 14.91 % under ACC administration, which were the lowest. |
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| ISSN: | 1756-4646 |