Development of an efficient heterologous protein expression platform in Aspergillus niger through genetic modification of a glucoamylase hyperproducing industrial strain

Development of an efficient heterologous protein expression platform in Aspergillus niger through genetic modification of a glucoamylase hyperproducing industrial strain

Abstract Background Aspergillus niger is widely used in industrial enzyme production due to its strong secretion capacity and the status of generally recognized as safe (GRAS). However, heterologous protein expression in A. niger is frequently constrained by high levels of background endogenous prot...

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Bibliographic Details
Main Authors: Fufan Gou, Dandan Liu, Chaohui Gong, Kefen Wang, Xingji Wang, Yefu Chen, Qian Liu, Chaoguang Tian
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Microbial Cell Factories
Subjects:
Aspergillus niger
Chassis strain
Glucoamylase
CRISPR/Cas9 genomic editing, heterologous protein
Expression platform
Recombinant strain
Online Access:https://doi.org/10.1186/s12934-025-02786-x
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https://doi.org/10.1186/s12934-025-02786-x

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