Navigating diagnostic uncertainty in fahr's disease: a case report with neuroimaging correlations
Fahr's disease is a rare neurological disorder which is characterized by the presence of abnormal, symmetrical, and bilateral calcifications within the basal ganglia and other cerebral areas. Seizures are 1 of the symptoms that may aid in its diagnosis. Fahr's disease is diagnosed in adult...
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Elsevier
2025-02-01
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| Series: | Radiology Case Reports |
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| author | Devyansh Nimodia, MBBS Pratapsingh Hanuman Parihar, MD Radiodiagnosis Sakshi Dudhe, MBBS Ravishankar Patil, MD Radiodiagnosis Paritosh N. Bhangale, MBBS Rishitha Kotla, MBBS |
| author_facet | Devyansh Nimodia, MBBS Pratapsingh Hanuman Parihar, MD Radiodiagnosis Sakshi Dudhe, MBBS Ravishankar Patil, MD Radiodiagnosis Paritosh N. Bhangale, MBBS Rishitha Kotla, MBBS |
| author_sort | Devyansh Nimodia, MBBS |
| collection | DOAJ |
| description | Fahr's disease is a rare neurological disorder which is characterized by the presence of abnormal, symmetrical, and bilateral calcifications within the basal ganglia and other cerebral areas. Seizures are 1 of the symptoms that may aid in its diagnosis. Fahr's disease is diagnosed in adults mostly. In this account, we describe the case of a male in his late 20s who was diagnosed with Fahr's disease. The patient experienced multiple seizures and severe headaches for the past 5 months. His medical history was not significant. Upon his admission to the emergency department, imaging studies (Computed Tomography and Magnetic Resonance Imaging) revealed the presence of bilateral and symmetrical calcifications situated within the bilateral corona radiata, bilateral centrum semiovale, bilateral gangliocapsular region, bilateral thalamus and bilateral dentate nucleus. Laboratory investigations ruled out alternative causes for secondary intracranial calcification. Moreover, the patient had no significant familial history. Considering the clinical, biological, and radiological evaluations, the diagnosis was concluded to align with a sporadic form of Fahr's disease.Although seizures are less common symptoms associated with Fahr's disease, the identification of bilateral and symmetrical calcifications in the basal ganglia and other regions on radiological imaging in a patient presenting with seizures should warrant consideration of this neurologic disorder, following the exclusion of other potential causes of intracranial calcification. |
| format | Article |
| id | doaj-art-c47494c236bb4954b5cbcc62e90e8bbb |
| institution | Kabale University |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-c47494c236bb4954b5cbcc62e90e8bbb2024-12-18T08:47:55ZengElsevierRadiology Case Reports1930-04332025-02-0120212521256Navigating diagnostic uncertainty in fahr's disease: a case report with neuroimaging correlationsDevyansh Nimodia, MBBS0Pratapsingh Hanuman Parihar, MD Radiodiagnosis1Sakshi Dudhe, MBBS2Ravishankar Patil, MD Radiodiagnosis3Paritosh N. Bhangale, MBBS4Rishitha Kotla, MBBS5Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India 442001; Corresponding author.Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India 442001Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India 442001Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India 442001Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India 442001Department of Psychiatry, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India 442001Fahr's disease is a rare neurological disorder which is characterized by the presence of abnormal, symmetrical, and bilateral calcifications within the basal ganglia and other cerebral areas. Seizures are 1 of the symptoms that may aid in its diagnosis. Fahr's disease is diagnosed in adults mostly. In this account, we describe the case of a male in his late 20s who was diagnosed with Fahr's disease. The patient experienced multiple seizures and severe headaches for the past 5 months. His medical history was not significant. Upon his admission to the emergency department, imaging studies (Computed Tomography and Magnetic Resonance Imaging) revealed the presence of bilateral and symmetrical calcifications situated within the bilateral corona radiata, bilateral centrum semiovale, bilateral gangliocapsular region, bilateral thalamus and bilateral dentate nucleus. Laboratory investigations ruled out alternative causes for secondary intracranial calcification. Moreover, the patient had no significant familial history. Considering the clinical, biological, and radiological evaluations, the diagnosis was concluded to align with a sporadic form of Fahr's disease.Although seizures are less common symptoms associated with Fahr's disease, the identification of bilateral and symmetrical calcifications in the basal ganglia and other regions on radiological imaging in a patient presenting with seizures should warrant consideration of this neurologic disorder, following the exclusion of other potential causes of intracranial calcification.http://www.sciencedirect.com/science/article/pii/S1930043324012809Basal gangliaCalcificationsFahrs diseaseNeuroimagingSeizures |
| spellingShingle | Devyansh Nimodia, MBBS Pratapsingh Hanuman Parihar, MD Radiodiagnosis Sakshi Dudhe, MBBS Ravishankar Patil, MD Radiodiagnosis Paritosh N. Bhangale, MBBS Rishitha Kotla, MBBS Navigating diagnostic uncertainty in fahr's disease: a case report with neuroimaging correlations Radiology Case Reports Basal ganglia Calcifications Fahrs disease Neuroimaging Seizures |
| title | Navigating diagnostic uncertainty in fahr's disease: a case report with neuroimaging correlations |
| title_full | Navigating diagnostic uncertainty in fahr's disease: a case report with neuroimaging correlations |
| title_fullStr | Navigating diagnostic uncertainty in fahr's disease: a case report with neuroimaging correlations |
| title_full_unstemmed | Navigating diagnostic uncertainty in fahr's disease: a case report with neuroimaging correlations |
| title_short | Navigating diagnostic uncertainty in fahr's disease: a case report with neuroimaging correlations |
| title_sort | navigating diagnostic uncertainty in fahr s disease a case report with neuroimaging correlations |
| topic | Basal ganglia Calcifications Fahrs disease Neuroimaging Seizures |
| url | http://www.sciencedirect.com/science/article/pii/S1930043324012809 |
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