Leveraging pleiotropy for joint analysis of genome-wide association studies with per trait interpretations.

Leveraging pleiotropy for joint analysis of genome-wide association studies with per trait interpretations.

We introduce pleiotropic association test (PAT) for joint analysis of multiple traits using genome-wide association study (GWAS) summary statistics. The method utilizes the decomposition of phenotypic covariation into genetic and environmental components to create a likelihood ratio test statistic f...

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Bibliographic Details
Main Authors: Kodi Taraszka, Noah Zaitlen, Eleazar Eskin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-11-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010447&type=printable
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