Pathways and Patterns of Cell Loss in Verified Alzheimer’s Disease: A Factor and Cluster Analysis of Clinico-Pathological Subgroups
Thirty-seven patients with neuropathologically verified Alzheimer's disease (AD) have been studied prospectively. A principal components analysis of neuron numbers in cortical and subcortical areas revealed two variables: Variable I with high loadings for the hippocampo-parahippocampo-parietal...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1994-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-1994-73-411 |
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| author | H. Förstl R. Levy A. Burns P. Luthert N. Cairns |
| author_facet | H. Förstl R. Levy A. Burns P. Luthert N. Cairns |
| author_sort | H. Förstl |
| collection | DOAJ |
| description | Thirty-seven patients with neuropathologically verified Alzheimer's disease (AD) have been studied prospectively. A principal components analysis of neuron numbers in cortical and subcortical areas revealed two variables: Variable I with high loadings for the hippocampo-parahippocampo-parietal neuron counts and Variable II with high loadings for coeruleo-frontal cell numbers. Both may reflect functional neuroanatomical connections which may act as pathways of neurodegeneration in AD. A cluster analysis based on these neuron numbers yielded three groups of patients: Cluster A with low hippocampo-parahippocampo-parietal cell counts, Cluster B with well-preserved neuron numbers, and Cluster C with low coeruleo-frontal neuron numbers. Differences in clinical features between these patient groups indicated the potential clinical relevance of these clusters. |
| format | Article |
| id | doaj-art-c46d3626eeef4b3281d302361d7f351d |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-c46d3626eeef4b3281d302361d7f351d2025-02-03T05:47:25ZengWileyBehavioural Neurology0953-41801875-85841994-01-0173-417518010.3233/BEN-1994-73-411Pathways and Patterns of Cell Loss in Verified Alzheimer’s Disease: A Factor and Cluster Analysis of Clinico-Pathological SubgroupsH. Förstl0R. Levy1A. Burns2P. Luthert3N. Cairns4Section of Old Age Psychiatry, Institute of Psychiatry, London, UKSection of Old Age Psychiatry, Institute of Psychiatry, London, UKSection of Old Age Psychiatry, Institute of Psychiatry, London, UKDepartment of Neuropathology, Institute of Psychiatry, London, UKMRC Alzheimer's Disease Brain Bank, Institute of Psychiatry, London, UKThirty-seven patients with neuropathologically verified Alzheimer's disease (AD) have been studied prospectively. A principal components analysis of neuron numbers in cortical and subcortical areas revealed two variables: Variable I with high loadings for the hippocampo-parahippocampo-parietal neuron counts and Variable II with high loadings for coeruleo-frontal cell numbers. Both may reflect functional neuroanatomical connections which may act as pathways of neurodegeneration in AD. A cluster analysis based on these neuron numbers yielded three groups of patients: Cluster A with low hippocampo-parahippocampo-parietal cell counts, Cluster B with well-preserved neuron numbers, and Cluster C with low coeruleo-frontal neuron numbers. Differences in clinical features between these patient groups indicated the potential clinical relevance of these clusters.http://dx.doi.org/10.3233/BEN-1994-73-411 |
| spellingShingle | H. Förstl R. Levy A. Burns P. Luthert N. Cairns Pathways and Patterns of Cell Loss in Verified Alzheimer’s Disease: A Factor and Cluster Analysis of Clinico-Pathological Subgroups Behavioural Neurology |
| title | Pathways and Patterns of Cell Loss in Verified Alzheimer’s Disease: A Factor and Cluster Analysis of Clinico-Pathological Subgroups |
| title_full | Pathways and Patterns of Cell Loss in Verified Alzheimer’s Disease: A Factor and Cluster Analysis of Clinico-Pathological Subgroups |
| title_fullStr | Pathways and Patterns of Cell Loss in Verified Alzheimer’s Disease: A Factor and Cluster Analysis of Clinico-Pathological Subgroups |
| title_full_unstemmed | Pathways and Patterns of Cell Loss in Verified Alzheimer’s Disease: A Factor and Cluster Analysis of Clinico-Pathological Subgroups |
| title_short | Pathways and Patterns of Cell Loss in Verified Alzheimer’s Disease: A Factor and Cluster Analysis of Clinico-Pathological Subgroups |
| title_sort | pathways and patterns of cell loss in verified alzheimer s disease a factor and cluster analysis of clinico pathological subgroups |
| url | http://dx.doi.org/10.3233/BEN-1994-73-411 |
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