Evaluating the efficacy of curcumin in the management of oral potentially malignant disorders: a systematic review and meta-analysis
Background Oral potentially malignant disorders (OPMDs) not only harbour the risk of malignant transformation but can also affect patients’ quality of life owing to severe symptoms. Therefore, there is an urgent need for therapeutic strategies to improve patients’ quality of life. The objective of t...
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PeerJ Inc.
2024-11-01
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| author | Wenjin Shi Qiuhao Wang Sixin Jiang Yuqi Wu Chunyu Li Yulang Xie Qianming Chen Xiaobo Luo |
| author_facet | Wenjin Shi Qiuhao Wang Sixin Jiang Yuqi Wu Chunyu Li Yulang Xie Qianming Chen Xiaobo Luo |
| author_sort | Wenjin Shi |
| collection | DOAJ |
| description | Background Oral potentially malignant disorders (OPMDs) not only harbour the risk of malignant transformation but can also affect patients’ quality of life owing to severe symptoms. Therefore, there is an urgent need for therapeutic strategies to improve patients’ quality of life. The objective of this meta-analysis was to comprehensively assess the efficacy of curcumin in the management of OPMDs. Methods PubMed, Embase, the Cochrane Library, and Web of Science were searched for clinical trials evaluating the efficacy of curcumin in the treatment of OPMDs from inception until March 2024. RevMan 5.4 software was used to perform statistical and subgroup analyses. Results Sixteen randomised controlled trials (1,089 patients) were selected. Curcumin exhibited comparable efficacy to conventional controls in alleviating pain (I2 = 98%, P = 0.49) and improving tongue protrusion (I2 = 94%, P = 0.51) in oral submucous fibrosis (OSF). Additionally, topical use of curcumin had an efficacy equivalent to that of conventional therapy in reducing pain (I2 = 83%, P = 0.31) and facilitating clinical remission (I2 = 67%, P = 0.38) of oral lichen planus (OLP). Conclusion The topical use of curcumin may palliate pain and promote clinical healing in OLP patients. Systemic curcumin can ameliorate the degree of pain and tongue protrusion in OSF. Therefore, our study suggests that curcumin could serve as an alternative treatment for managing OPMDs with lower medical toxicity than steroids, especially when steroids are not suitable. Further studies with larger sample sizes and adequate follow-up periods are required to validate our results. |
| format | Article |
| id | doaj-art-c44d3af92b8a4d66980481441f8ce2c5 |
| institution | Kabale University |
| issn | 2167-8359 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | PeerJ Inc. |
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| series | PeerJ |
| spelling | doaj-art-c44d3af92b8a4d66980481441f8ce2c52024-11-17T15:05:24ZengPeerJ Inc.PeerJ2167-83592024-11-0112e1849210.7717/peerj.18492Evaluating the efficacy of curcumin in the management of oral potentially malignant disorders: a systematic review and meta-analysisWenjin ShiQiuhao WangSixin JiangYuqi WuChunyu LiYulang XieQianming ChenXiaobo LuoBackground Oral potentially malignant disorders (OPMDs) not only harbour the risk of malignant transformation but can also affect patients’ quality of life owing to severe symptoms. Therefore, there is an urgent need for therapeutic strategies to improve patients’ quality of life. The objective of this meta-analysis was to comprehensively assess the efficacy of curcumin in the management of OPMDs. Methods PubMed, Embase, the Cochrane Library, and Web of Science were searched for clinical trials evaluating the efficacy of curcumin in the treatment of OPMDs from inception until March 2024. RevMan 5.4 software was used to perform statistical and subgroup analyses. Results Sixteen randomised controlled trials (1,089 patients) were selected. Curcumin exhibited comparable efficacy to conventional controls in alleviating pain (I2 = 98%, P = 0.49) and improving tongue protrusion (I2 = 94%, P = 0.51) in oral submucous fibrosis (OSF). Additionally, topical use of curcumin had an efficacy equivalent to that of conventional therapy in reducing pain (I2 = 83%, P = 0.31) and facilitating clinical remission (I2 = 67%, P = 0.38) of oral lichen planus (OLP). Conclusion The topical use of curcumin may palliate pain and promote clinical healing in OLP patients. Systemic curcumin can ameliorate the degree of pain and tongue protrusion in OSF. Therefore, our study suggests that curcumin could serve as an alternative treatment for managing OPMDs with lower medical toxicity than steroids, especially when steroids are not suitable. Further studies with larger sample sizes and adequate follow-up periods are required to validate our results.https://peerj.com/articles/18492.pdfCurcuminOral potentially malignant disordersOral submucous fibrosisOral lichen planusSystematic review |
| spellingShingle | Wenjin Shi Qiuhao Wang Sixin Jiang Yuqi Wu Chunyu Li Yulang Xie Qianming Chen Xiaobo Luo Evaluating the efficacy of curcumin in the management of oral potentially malignant disorders: a systematic review and meta-analysis PeerJ Curcumin Oral potentially malignant disorders Oral submucous fibrosis Oral lichen planus Systematic review |
| title | Evaluating the efficacy of curcumin in the management of oral potentially malignant disorders: a systematic review and meta-analysis |
| title_full | Evaluating the efficacy of curcumin in the management of oral potentially malignant disorders: a systematic review and meta-analysis |
| title_fullStr | Evaluating the efficacy of curcumin in the management of oral potentially malignant disorders: a systematic review and meta-analysis |
| title_full_unstemmed | Evaluating the efficacy of curcumin in the management of oral potentially malignant disorders: a systematic review and meta-analysis |
| title_short | Evaluating the efficacy of curcumin in the management of oral potentially malignant disorders: a systematic review and meta-analysis |
| title_sort | evaluating the efficacy of curcumin in the management of oral potentially malignant disorders a systematic review and meta analysis |
| topic | Curcumin Oral potentially malignant disorders Oral submucous fibrosis Oral lichen planus Systematic review |
| url | https://peerj.com/articles/18492.pdf |
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