Aging-related changes of miR-23b-3p expression in extracellular vesicles from mesenchymal stromal cells affect TGFBR3 signaling

Aging-related changes of miR-23b-3p expression in extracellular vesicles from mesenchymal stromal cells affect TGFBR3 signaling

Abstract Extracellular vesicles (EVs), which carry biological mediators such as microRNAs (miRNAs) and cytokines, play a crucial role in regulating recipient tissues and are considered a key mechanism of action in cell therapy. However, it has been found that cellular aging in donor cells significan...

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Main Authors: Maki Itokazu, Toshiyuki Takehara, Kensuke Toriumi, Natsumi Iwawaki, Tatsufumi Mori, Yuta Ondoera, Yuji Higashimoto, Koji Goto, Hidekazu Yamada, Takeshi Teramura
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-06982-y
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