BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation

BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation

Abstract Cognitive impairment is a significant complication of type 2 diabetes mellitus (T2DM). However, the mechanisms underlying the development of cognitive dysfunction in individuals with T2DM remain elusive. Herein, we discussed the role of Bmal1, a core circadian rhythm-regulating gene, in the...

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Main Authors:	Jialu Xu, Chunyu Li, Rongping Fan, Jiaxin Yin, Lei Xie, Xuemin Peng, Jing Tao, Weijie Xu, Shujun Zhang, Xiaoli Shi, Kun Dong, Xuefeng Yu, Xi Chen, Yan Yang
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Series:	Cell Communication and Signaling
Subjects:	BMAL1 T2DM-associated cognitive impairment AREG/PI3K/Akt/GSK-3β pathway
Online Access:	https://doi.org/10.1186/s12964-024-02019-5
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