Molecular basis for the regulation of human phosphorylase kinase by phosphorylation and Ca2+

Abstract Phosphorylase kinase (PhK) regulates the degradation of glycogen by integrating diverse signals, providing energy to the organism. Dysfunctional mutations may directly lead to Glycogen Storage Disease type IX (GSD IX), whereas the abnormal expression of PhK is also associated with tumors. H...

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Bibliographic Details
Main Authors: Ruifang Ma, Bowen Du, Chen Shi, Lei Wang, Fuxing Zeng, Jie Han, Huiyi Guan, Yong Wang, Kaige Yan
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58363-8
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