The C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in mice

The C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in mice

Avian influenza viruses (AIV) H5N8 clade 2.3.4.4 pose a public health threat but the viral factors relevant for its potential adaptation to mammals are largely unknown. The non-structural protein 1 (NS1) of influenza viruses is an essential interferon antagonist. It commonly consists of 230 amino ac...

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Bibliographic Details
Main Authors: Claudia Blaurock, Ulrike Blohm, Christine Luttermann, Julia Holzerland, David Scheibner, Alexander Schäfer, Allison Groseth, Thomas C. Mettenleiter, Elsayed M. Abdelwhab
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Emerging Microbes and Infections
Subjects:
Avian influenza virus
H5N8 clade 2.3.4.4
Interspecies Transmission
mammals
NS1
virulence
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2021.1971568
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