Modulating Endoplasmic Reticulum Stress in Gastrointestinal Cancers: Insights from Traditional Chinese Medicine

Modulating Endoplasmic Reticulum Stress in Gastrointestinal Cancers: Insights from Traditional Chinese Medicine

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) play critical roles in tumorigenesis, cancer progression, and drug resistance. Persistent activation of the ER stress system enhances the survival capacities of malignant tumor cells, including increased proliferation, invasio...

Full description

Saved in:

Bibliographic Details
Main Authors:	Qinyi Li, Xiaohong Zhao, Huan Yang, Xiaolong Zhu, Xinbing Sui, Jiao Feng
Format:	Article
Language:	English
Published:	MDPI AG 2024-11-01
Series:	Pharmaceuticals
Subjects:	endoplasmic reticulum stress unfolded protein response traditional Chinese medicine gastrointestinal tumors
Online Access:	https://www.mdpi.com/1424-8247/17/12/1599
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

MAM-mediated mitophagy and endoplasmic reticulum stress: the hidden regulators of ischemic stroke
by: Ziyi Jia, et al.
Published: (2024-11-01)

Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases
by: Jiao Lv, et al.
Published: (2025-01-01)

Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury
by: Kai Yang, et al.
Published: (2024-11-01)

Endoplasmic Reticulum Stress in Bronchopulmonary Dysplasia: Contributor or Consequence?
by: Tzong-Jin Wu, et al.
Published: (2024-10-01)

Quantitative proteomics reveals the mechanism of endoplasmic reticulum stress-mediated pulmonary fibrosis in mice
by: Heng Li, et al.
Published: (2024-10-01)

Insights into the molecular underlying mechanisms and therapeutic potential of endoplasmic reticulum stress in sensorineural hearing loss
by: Guanzhen Li, et al.
Published: (2024-12-01)

Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells
by: Hu Ke, et al.
Published: (2024-12-01)

Endoplasmic reticulum stress in the salivary glands of patients with primary and associated Sjögren’s disease, and non-Sjögren’s sicca syndrome: a comparative analysis and the influence of chloroquine
by: Graziela Vieira Cavalcanti, et al.
Published: (2025-01-01)

Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023
by: Wang Junli, et al.
Published: (2025-01-01)

Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen
by: Rachel Sharninghausen, et al.
Published: (2024-11-01)

Bioinformatics Analysis and Experimental Validation of Endoplasmic Reticulum Stress-Related Genes in Osteoporosis
by: Zheng Y, et al.
Published: (2024-11-01)

Unfolded protein response during the progression of colorectal carcinogenesis
by: Cesar Augusto Sobrinho, et al.
Published: (2025-01-01)

Connections Between Endoplasmic Reticulum Stress and Prognosis of Hepatocarcinoma
by: Ming Wu, et al.
Published: (2024-11-01)

Regulation of calcium homeostasis in endoplasmic reticulum–mitochondria crosstalk: implications for skeletal muscle atrophy
by: Xuexin Li, et al.
Published: (2025-01-01)

Cyclosporine-A induces endoplasmic reticulum stress in human gingival fibroblasts – An in vitro study
by: Suresh Ranga Rao, et al.
Published: (2018-09-01)

Goose astrovirus induces apoptosis and endoplasmic reticulum stress in gosling hepatocytes
by: Zhihua Lu, et al.
Published: (2025-01-01)

CSE-8, a filamentous fungus-specific Shr3-like chaperone, facilitates endoplasmic reticulum exit of chitin synthase CHS-3 (class I) in Neurospora crassa
by: Samantha Verónica González-Téllez, et al.
Published: (2025-01-01)

Endoplasmic reticulum stress improved chicken tenderness, promoted apoptosis and autophagy during postmortem ageing
by: Yuwei Chai, et al.
Published: (2024-07-01)

Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress
by: Nevertyty Mohamed Mahmoud, et al.
Published: (2024-12-01)

Isoliquiritigenin induced hepatotoxicity and endoplasmic reticulum stress in zebrafish embryos
by: Deliang Hu, et al.
Published: (2024-11-01)

Identification of critical endoplasmic reticulum stress-related genes in advanced atherosclerotic plaque
by: Ning Zhao, et al.
Published: (2025-01-01)

Endoplasmic reticulum stress: The underlying mechanism of chronic pain
by: Tongtong Liu, et al.
Published: (2024-11-01)

Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma
by: Jin-Xing Wang, et al.
Published: (2025-01-01)

Dioscin pretreatment ameliorates ferroptosis in cardiomyocytes after myocardial infarction via inhibiting endoplasmic reticulum stress
by: Chang Wu, et al.
Published: (2025-01-01)

Gallic acid showed neuroprotection against endoplasmic reticulum stress in rats
by: Abdulmutalip Karaaslanlı, et al.
Published: (2025-01-01)

The Role and Interactive Mechanism of Endoplasmic Reticulum Stress and Ferroptosis in Musculoskeletal Disorders
by: Zhou Guo, et al.
Published: (2024-10-01)

Targeting endoplasmic reticulum stress‐induced lymphatic dysfunction for mitigating bisphosphonate‐related osteonecrosis
by: Ziyue Qin, et al.
Published: (2024-11-01)

Prolonged stress-induced depression-like behaviors in aged rats are mediated by endoplasmic reticulum stress and apoptosis in the hippocampus
by: Arshad Ghaffari-Nasab, et al.
Published: (2024-01-01)

Role of the endoplasmic reticulum in mechanisms of aging and formation of senescent cells
by: Lev Salnikov
Published: (2024-01-01)

Proteomic Study of Mitochondria-Associated Endoplasmic Reticulum in Saccharomyces cerevisiae under Different Nutritional Conditions
by: Yan SUN, et al.
Published: (2024-11-01)

Research progress of endoplasmic reticulum stress in peritoneal dialysis
by: Li Yan-ling, et al.
Published: (2025-01-01)

Circadian regulation of endoplasmic reticulum calcium response in cultured mouse astrocytes
by: Ji Eun Ryu, et al.
Published: (2024-11-01)

Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum
by: Pyae Hein Htet, et al.
Published: (2024-12-01)

Single-cell transcriptomics of vomeronasal neuroepithelium reveals a differential endoplasmic reticulum environment amongst neuronal subtypes
by: GVS Devakinandan, et al.
Published: (2024-12-01)

Endoplasmic Reticulum Calcium Signaling in Hippocampal Neurons
by: Vyacheslav M. Shkryl
Published: (2024-12-01)

Infancy‐onset diabetes caused by de‐regulated AMPylation of the human endoplasmic reticulum chaperone BiP
by: Luke A Perera, et al.
Published: (2023-01-01)

PTGS2/GRP78 Activation Triggers Endoplasmic Reticulum Stress Leading to Lipid Metabolism Disruption and Cell Apoptosis, Exacerbating Damage in Bovine Mastitis
by: Yan Chen, et al.
Published: (2024-11-01)

Poricoic acid A attenuates renal fibrosis by inhibiting endoplasmic reticulum stress-mediated apoptosis
by: Hui Zhao, et al.
Published: (2024-11-01)

PDZD8 Augments Endoplasmic Reticulum-Mitochondria Contact and Regulates Ca2+ Dynamics and Cypd Expression to Induce Pancreatic β-Cell Death during Diabetes
by: Yongxin Liu, et al.
Published: (2024-11-01)

Selenium participates in the formation of kidney stones by alleviating endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells
by: Xiaozhe Su, et al.
Published: (2024-12-01)