Formulation development, characterization, and mechanistic PBPK modeling of metoclopramide loaded halloysite nanotube (HNT) based drug-in-adhesive type transdermal drug delivery system

Formulation development, characterization, and mechanistic PBPK modeling of metoclopramide loaded halloysite nanotube (HNT) based drug-in-adhesive type transdermal drug delivery system

Abstract Metoclopramide is an antiemetic agent prescribed for motion sickness, cancer chemotherapy, and pregnancy. The present work aimed to design a metoclopramide-loaded halloysite nanotubes (HNTs) drug-in-adhesive transdermal drug delivery system. Four formulations F1, F2, and F3 with different r...

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Bibliographic Details
Main Authors: Monica Parkash, Muhammad Harris Shoaib, Muhammad Sikandar, Rabia Ismail Yousuf, Muhammad Talha Saleem, Farrukh Rafiq Ahmed, Fahad Siddiqui
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Transdermal, Halloysite nanotube
Metoclopramide
DURO-TAK 387–2510
Drug-in-adhesive
Physiological based pharmacokinetics (PBPK)
Online Access:https://doi.org/10.1038/s41598-024-80089-8
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