Trends in gastric cancer burden in the Western Pacific region from 1990 to 2021 and projections to 2040
BackgroundGastric cancer (GC) is a major public health concern, particularly in the Western Pacific, a high-incidence region that bears significant economic and social burdens.MethodsBased on data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we conducted a comprehensive...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1506479/full |
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| author | Tao Zhang Yiqun Zhang Yiqun Zhang Yiqun Zhang Xiaofei Leng |
| author_facet | Tao Zhang Yiqun Zhang Yiqun Zhang Yiqun Zhang Xiaofei Leng |
| author_sort | Tao Zhang |
| collection | DOAJ |
| description | BackgroundGastric cancer (GC) is a major public health concern, particularly in the Western Pacific, a high-incidence region that bears significant economic and social burdens.MethodsBased on data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we conducted a comprehensive analysis of trends in the burden of GC in the Western Pacific from 1990 to 2021. We compared these trends with global and World Health Organization regional patterns, with a particular focus on geographic, gender, and age disparities. Health inequality was analyzed by comparing countries with different Socio-demographic Index (SDI) levels. Future trends in age-standardized rates were projected using the Bayesian Age-Period-Cohort (BAPC) model.ResultsThe GC burden of Western Pacific region remains above the global average, but improvements have outpaced global trends. China carries the highest burden, accounting for over half of regional cases, deaths, and disability-adjusted life years. While South Korea and Japan also experience high burdens, they have achieved notable reductions. Males consistently face higher burdens across age groups. Health inequality analysis shows narrowing gaps between high- and low-SDI countries, with the burden shifting toward less developed nations. BAPC model projections indicate a further decline in the GC burden by 2040.ConclusionDespite substantial progress in countries like Japan and South Korea, continued focus is needed on less developed regions to reduce the remaining GC burden in the future. |
| format | Article |
| id | doaj-art-c4080f40e9e14c09b823eca4c3a7a4a4 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-c4080f40e9e14c09b823eca4c3a7a4a42025-08-20T02:47:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.15064791506479Trends in gastric cancer burden in the Western Pacific region from 1990 to 2021 and projections to 2040Tao Zhang0Yiqun Zhang1Yiqun Zhang2Yiqun Zhang3Xiaofei Leng4Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Gynecology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, ChinaDepartment of Gynecology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaBackgroundGastric cancer (GC) is a major public health concern, particularly in the Western Pacific, a high-incidence region that bears significant economic and social burdens.MethodsBased on data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we conducted a comprehensive analysis of trends in the burden of GC in the Western Pacific from 1990 to 2021. We compared these trends with global and World Health Organization regional patterns, with a particular focus on geographic, gender, and age disparities. Health inequality was analyzed by comparing countries with different Socio-demographic Index (SDI) levels. Future trends in age-standardized rates were projected using the Bayesian Age-Period-Cohort (BAPC) model.ResultsThe GC burden of Western Pacific region remains above the global average, but improvements have outpaced global trends. China carries the highest burden, accounting for over half of regional cases, deaths, and disability-adjusted life years. While South Korea and Japan also experience high burdens, they have achieved notable reductions. Males consistently face higher burdens across age groups. Health inequality analysis shows narrowing gaps between high- and low-SDI countries, with the burden shifting toward less developed nations. BAPC model projections indicate a further decline in the GC burden by 2040.ConclusionDespite substantial progress in countries like Japan and South Korea, continued focus is needed on less developed regions to reduce the remaining GC burden in the future.https://www.frontiersin.org/articles/10.3389/fonc.2025.1506479/fullgastric cancerGBDwestern pacific regionincidencemortalityDALYs |
| spellingShingle | Tao Zhang Yiqun Zhang Yiqun Zhang Yiqun Zhang Xiaofei Leng Trends in gastric cancer burden in the Western Pacific region from 1990 to 2021 and projections to 2040 Frontiers in Oncology gastric cancer GBD western pacific region incidence mortality DALYs |
| title | Trends in gastric cancer burden in the Western Pacific region from 1990 to 2021 and projections to 2040 |
| title_full | Trends in gastric cancer burden in the Western Pacific region from 1990 to 2021 and projections to 2040 |
| title_fullStr | Trends in gastric cancer burden in the Western Pacific region from 1990 to 2021 and projections to 2040 |
| title_full_unstemmed | Trends in gastric cancer burden in the Western Pacific region from 1990 to 2021 and projections to 2040 |
| title_short | Trends in gastric cancer burden in the Western Pacific region from 1990 to 2021 and projections to 2040 |
| title_sort | trends in gastric cancer burden in the western pacific region from 1990 to 2021 and projections to 2040 |
| topic | gastric cancer GBD western pacific region incidence mortality DALYs |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1506479/full |
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