The role of tissue factor in metastasising, neoangiogenesis and hemostasis in cancer
Tissue factor, being the main initiator of the blood coagulation in vivo, is involved in a number of physiological processes, such as angiogenesis or cell migration. These processes are not only significant for normal physiology, but also play a role in the development and progression of oncological...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-07-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/350 |
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| _version_ | 1849241284433149952 |
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| author | T. A. Kovalenko M. A. Panteleev A. N. Sveshnikova |
| author_facet | T. A. Kovalenko M. A. Panteleev A. N. Sveshnikova |
| author_sort | T. A. Kovalenko |
| collection | DOAJ |
| description | Tissue factor, being the main initiator of the blood coagulation in vivo, is involved in a number of physiological processes, such as angiogenesis or cell migration. These processes are not only significant for normal physiology, but also play a role in the development and progression of oncological diseases. This review presents data on the structure of tissue factor, its expression in normal conditions and in cancer, its role in thrombosis development associated with cancer, in angiogenesis and in metastasis. The involvement of tissue factor in such a wide range of physiological processes important for the progression of cancer makes it an attractive target molecule for therapy. |
| format | Article |
| id | doaj-art-c3fe6d14f2cc46f48dd7c0fb361c3a2b |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-c3fe6d14f2cc46f48dd7c0fb361c3a2b2025-08-20T04:00:13ZrusABV-pressОнкогематология1818-83462413-40232019-07-01142708510.17650/1818-8346-2019-14-2-70-85315The role of tissue factor in metastasising, neoangiogenesis and hemostasis in cancerT. A. Kovalenko0M. A. Panteleev1A. N. Sveshnikova2Lomonosov Moscow State University; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of SciencesLomonosov Moscow State University; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia;Lomonosov Moscow State University; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia; Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia;Tissue factor, being the main initiator of the blood coagulation in vivo, is involved in a number of physiological processes, such as angiogenesis or cell migration. These processes are not only significant for normal physiology, but also play a role in the development and progression of oncological diseases. This review presents data on the structure of tissue factor, its expression in normal conditions and in cancer, its role in thrombosis development associated with cancer, in angiogenesis and in metastasis. The involvement of tissue factor in such a wide range of physiological processes important for the progression of cancer makes it an attractive target molecule for therapy.https://oncohematology.abvpress.ru/ongm/article/view/350extrinsic tenaseblood coagulationfactor viiareceptor par2neoplasm |
| spellingShingle | T. A. Kovalenko M. A. Panteleev A. N. Sveshnikova The role of tissue factor in metastasising, neoangiogenesis and hemostasis in cancer Онкогематология extrinsic tenase blood coagulation factor viia receptor par2 neoplasm |
| title | The role of tissue factor in metastasising, neoangiogenesis and hemostasis in cancer |
| title_full | The role of tissue factor in metastasising, neoangiogenesis and hemostasis in cancer |
| title_fullStr | The role of tissue factor in metastasising, neoangiogenesis and hemostasis in cancer |
| title_full_unstemmed | The role of tissue factor in metastasising, neoangiogenesis and hemostasis in cancer |
| title_short | The role of tissue factor in metastasising, neoangiogenesis and hemostasis in cancer |
| title_sort | role of tissue factor in metastasising neoangiogenesis and hemostasis in cancer |
| topic | extrinsic tenase blood coagulation factor viia receptor par2 neoplasm |
| url | https://oncohematology.abvpress.ru/ongm/article/view/350 |
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