Integrating single-cell sequencing and transcriptome analysis to unravel the mechanistic role of sialylation-related genes in sepsis-induced acute respiratory distress syndrome

Integrating single-cell sequencing and transcriptome analysis to unravel the mechanistic role of sialylation-related genes in sepsis-induced acute respiratory distress syndrome

BackgroundStudies have shown that sialylation of C1 esterase inhibitors is crucial for their interaction with histones, and histone-C1 esterase inhibitor complexes are detected in acute respiratory distress syndrome (ARDS), suggesting a potential role of sialylation in ARDS. However, the specific fu...

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Bibliographic Details
Main Authors: Xiaobing Liu, Yake Huang, Hao Zhang, Xia Yang, Quanxing Liu, Jigang Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
sepsis-induced acute respiratory distress syndrome
sialylation
nomogram
single-cell RNA sequencing
key genes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1528769/full
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