Participants in Treponema pallidum pathogenesis: progress in functional proteins
Treponema pallidum subsp. pallidum (T. pallidum) is the causative agent of syphilis, a chronic sexually transmitted disease that leads to widespread organ damage. The pathogenesis of syphilis involves crucial functional proteins that facilitate bacterial adhesion to host cells, invasion, disseminati...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1632677/full |
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| _version_ | 1849222450116558848 |
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| author | Wei Zuo Yongjian Xiao Qing Xiang Shuangwen Xiao Yafeng Xie |
| author_facet | Wei Zuo Yongjian Xiao Qing Xiang Shuangwen Xiao Yafeng Xie |
| author_sort | Wei Zuo |
| collection | DOAJ |
| description | Treponema pallidum subsp. pallidum (T. pallidum) is the causative agent of syphilis, a chronic sexually transmitted disease that leads to widespread organ damage. The pathogenesis of syphilis involves crucial functional proteins that facilitate bacterial adhesion to host cells, invasion, dissemination, immune evasion, and inflammatory responses. Investigating these proteins is crucial for the development of innovative diagnostic tools, vaccines, and therapies. However, the intricate nature of T. pallidum and the inability to culture in vitro hinder our comprehensive understanding of these proteins. This review article presents innovative understandings of the pathogenesis of T. pallidum functional proteins, building upon existing knowledge. This paper establishes a foundation for comprehending the current knowledge landscape and outlining future research avenues. |
| format | Article |
| id | doaj-art-c3e956f07c1d4255bbfd9990082b2ff3 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c3e956f07c1d4255bbfd9990082b2ff32025-08-26T05:28:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16326771632677Participants in Treponema pallidum pathogenesis: progress in functional proteinsWei ZuoYongjian XiaoQing XiangShuangwen XiaoYafeng XieTreponema pallidum subsp. pallidum (T. pallidum) is the causative agent of syphilis, a chronic sexually transmitted disease that leads to widespread organ damage. The pathogenesis of syphilis involves crucial functional proteins that facilitate bacterial adhesion to host cells, invasion, dissemination, immune evasion, and inflammatory responses. Investigating these proteins is crucial for the development of innovative diagnostic tools, vaccines, and therapies. However, the intricate nature of T. pallidum and the inability to culture in vitro hinder our comprehensive understanding of these proteins. This review article presents innovative understandings of the pathogenesis of T. pallidum functional proteins, building upon existing knowledge. This paper establishes a foundation for comprehending the current knowledge landscape and outlining future research avenues.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1632677/fullTreponema pallidumfunctional proteininteractionpathogenesisimmune evasion |
| spellingShingle | Wei Zuo Yongjian Xiao Qing Xiang Shuangwen Xiao Yafeng Xie Participants in Treponema pallidum pathogenesis: progress in functional proteins Frontiers in Immunology Treponema pallidum functional protein interaction pathogenesis immune evasion |
| title | Participants in Treponema pallidum pathogenesis: progress in functional proteins |
| title_full | Participants in Treponema pallidum pathogenesis: progress in functional proteins |
| title_fullStr | Participants in Treponema pallidum pathogenesis: progress in functional proteins |
| title_full_unstemmed | Participants in Treponema pallidum pathogenesis: progress in functional proteins |
| title_short | Participants in Treponema pallidum pathogenesis: progress in functional proteins |
| title_sort | participants in treponema pallidum pathogenesis progress in functional proteins |
| topic | Treponema pallidum functional protein interaction pathogenesis immune evasion |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1632677/full |
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