Cooperation of LIM domain‐binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia

Cooperation of LIM domain‐binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia

Abstract Genomic defects with large effect size can help elucidate unknown pathologic architecture of mental disorders. We previously reported on a patient with schizophrenia and a balanced translocation between chromosomes 4 and 13 and found that the breakpoint within chromosome 4 is located near t...

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Main Authors: Tetsuo Ohnishi, Yuji Kiyama, Fumiko Arima‐Yoshida, Mitsutaka Kadota, Tomoe Ichikawa, Kazuyuki Yamada, Akiko Watanabe, Hisako Ohba, Kaori Tanaka, Akihiro Nakaya, Yasue Horiuchi, Yoshimi Iwayama, Manabu Toyoshima, Itone Ogawa, Chie Shimamoto‐Mitsuyama, Motoko Maekawa, Shabeesh Balan, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Yayoi Nozaki, Rumi Kurokawa, Kazuhiro Suzuki, Akane Yoshikawa, Tomoko Toyota, Toshihiko Hosoya, Hiroyuki Okuno, Haruhiko Bito, Masanari Itokawa, Shigehiro Kuraku, Toshiya Manabe, Takeo Yoshikawa
Format: Article
Language:English
Published: Springer Nature 2021-03-01
Series:EMBO Molecular Medicine
Subjects:
amygdala
balanced chromosomal translocation
behavior
ChIP‐seq
knockout mouse
Online Access:https://doi.org/10.15252/emmm.202012574
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