Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults
BackgroundPosttraumatic stress disorder (PTSD) is associated with the development of dementia. However, the link between PTSD and preclinical Alzheimer’s disease pathology (amyloid β [Aβ]) remains controversial. Moreover, the correlation between the severity of PTSD with Aβ levels remains unknown.Me...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1422862/full |
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| author | Lei Zhang Yi-Miao Gong Yi-Miao Gong San-Wang Wang San-Wang Wang Pei-Ling Shi Pei-Ling Shi Pei-Ling Shi Ming-Zhe Li Ming-Zhe Li Xin Wen Xin Wen Di-Xin Wang Yong-Bo Zheng Yong-Bo Zheng Yong Han Yong Han Yong Han |
| author_facet | Lei Zhang Yi-Miao Gong Yi-Miao Gong San-Wang Wang San-Wang Wang Pei-Ling Shi Pei-Ling Shi Pei-Ling Shi Ming-Zhe Li Ming-Zhe Li Xin Wen Xin Wen Di-Xin Wang Yong-Bo Zheng Yong-Bo Zheng Yong Han Yong Han Yong Han |
| author_sort | Lei Zhang |
| collection | DOAJ |
| description | BackgroundPosttraumatic stress disorder (PTSD) is associated with the development of dementia. However, the link between PTSD and preclinical Alzheimer’s disease pathology (amyloid β [Aβ]) remains controversial. Moreover, the correlation between the severity of PTSD with Aβ levels remains unknown.MethodsThis cross-sectional study sought to investigate the associations of PTSD symptoms with global and regional brain Aβ burden. To this end, data were obtained from participants in the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) Study. In addition, we explored the association between the severity of PTSD symptoms and Aβ levels.ResultsA total of 4,228 participants aged 65 to 85 years were included in the final analysis. The results showed that PTSD symptoms were significantly associated with higher global Aβ levels (1.15 ± 0.20 vs. 1.09 ± 0.19; β = 0.056; p < 0.001), after adjusting for covariates. The association between PTSD symptoms and Aβ levels was not affected by sex, age, ApoE genotype, or psychiatric diseases. Similarly, PTSD symptoms were significantly associated with Aβ levels in all subregions, including the anterior cingulate, posterior cingulate, parietal cortex, precuneus, temporal cortex, and frontal cortex. In addition, the group with severe PTSD symptoms (1.22 ± 0.24) exhibited higher global Aβ levels than the groups with moderate (1.14 ± 0.19) or mild (1.12 ± 0.20) symptoms or the control (1.08 ± 0.18), with p < 0.001.ConclusionThe findings imply a close relationship between PTSD and brain Aβ levels, irrespective of sex, age, ApoE genotype, or psychiatric diseases. More well-designed studies are needed to further explore the relationship and mechanism underlying the association between PTSD and Aβ burden. |
| format | Article |
| id | doaj-art-c3bc5fb6c11a469e896edab657ef0d90 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-c3bc5fb6c11a469e896edab657ef0d902024-12-03T06:30:23ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-12-011610.3389/fnagi.2024.14228621422862Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adultsLei Zhang0Yi-Miao Gong1Yi-Miao Gong2San-Wang Wang3San-Wang Wang4Pei-Ling Shi5Pei-Ling Shi6Pei-Ling Shi7Ming-Zhe Li8Ming-Zhe Li9Xin Wen10Xin Wen11Di-Xin Wang12Yong-Bo Zheng13Yong-Bo Zheng14Yong Han15Yong Han16Yong Han17Department of Nutrition,Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No. 2018RU006), Peking University, Beijing, ChinaPeking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No. 2018RU006), Peking University, Beijing, ChinaDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaHenan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder, Xinxiang, ChinaHenan Key Lab of Biological Psychiatry, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang Medical University, Xinxiang, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No. 2018RU006), Peking University, Beijing, ChinaPeking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No. 2018RU006), Peking University, Beijing, ChinaPeking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, ChinaKey Laboratory of Brain Health Intelligent Evaluation and Intervention, Ministry of Education (Beijing Institute of Technology), Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No. 2018RU006), Peking University, Beijing, ChinaPeking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, ChinaDepartment of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaHenan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder, Xinxiang, ChinaHenan Key Lab of Biological Psychiatry, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang Medical University, Xinxiang, ChinaBackgroundPosttraumatic stress disorder (PTSD) is associated with the development of dementia. However, the link between PTSD and preclinical Alzheimer’s disease pathology (amyloid β [Aβ]) remains controversial. Moreover, the correlation between the severity of PTSD with Aβ levels remains unknown.MethodsThis cross-sectional study sought to investigate the associations of PTSD symptoms with global and regional brain Aβ burden. To this end, data were obtained from participants in the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) Study. In addition, we explored the association between the severity of PTSD symptoms and Aβ levels.ResultsA total of 4,228 participants aged 65 to 85 years were included in the final analysis. The results showed that PTSD symptoms were significantly associated with higher global Aβ levels (1.15 ± 0.20 vs. 1.09 ± 0.19; β = 0.056; p < 0.001), after adjusting for covariates. The association between PTSD symptoms and Aβ levels was not affected by sex, age, ApoE genotype, or psychiatric diseases. Similarly, PTSD symptoms were significantly associated with Aβ levels in all subregions, including the anterior cingulate, posterior cingulate, parietal cortex, precuneus, temporal cortex, and frontal cortex. In addition, the group with severe PTSD symptoms (1.22 ± 0.24) exhibited higher global Aβ levels than the groups with moderate (1.14 ± 0.19) or mild (1.12 ± 0.20) symptoms or the control (1.08 ± 0.18), with p < 0.001.ConclusionThe findings imply a close relationship between PTSD and brain Aβ levels, irrespective of sex, age, ApoE genotype, or psychiatric diseases. More well-designed studies are needed to further explore the relationship and mechanism underlying the association between PTSD and Aβ burden.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1422862/fullamyloidposttraumatic stress disorder symptomolder adultcross-sectional studydementia |
| spellingShingle | Lei Zhang Yi-Miao Gong Yi-Miao Gong San-Wang Wang San-Wang Wang Pei-Ling Shi Pei-Ling Shi Pei-Ling Shi Ming-Zhe Li Ming-Zhe Li Xin Wen Xin Wen Di-Xin Wang Yong-Bo Zheng Yong-Bo Zheng Yong Han Yong Han Yong Han Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults Frontiers in Aging Neuroscience amyloid posttraumatic stress disorder symptom older adult cross-sectional study dementia |
| title | Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults |
| title_full | Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults |
| title_fullStr | Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults |
| title_full_unstemmed | Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults |
| title_short | Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults |
| title_sort | associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults |
| topic | amyloid posttraumatic stress disorder symptom older adult cross-sectional study dementia |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1422862/full |
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