Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice
Abstract Medium- and long-chain triacylglycerols (MLCTs) are regarded as healthy premium oils; however, the health benefits of novel MLCTs enriched with lauric and α-linolenic acids are still not fully understood. This study examined the health benefits of lauric-α-linolenic structural lipids (ALSL)...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-024-00349-9 |
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| author | Ying Huang Wangxin Liu Xianliang Luo Minjie Zhao Jing Wang Sami Ullah Wei Wei Fengqin Feng |
| author_facet | Ying Huang Wangxin Liu Xianliang Luo Minjie Zhao Jing Wang Sami Ullah Wei Wei Fengqin Feng |
| author_sort | Ying Huang |
| collection | DOAJ |
| description | Abstract Medium- and long-chain triacylglycerols (MLCTs) are regarded as healthy premium oils; however, the health benefits of novel MLCTs enriched with lauric and α-linolenic acids are still not fully understood. This study examined the health benefits of lauric-α-linolenic structural lipids (ALSL) and physical mixture (PM) with a similar fatty acid composition in mice with obesity induced by the high-fat diet (HFD). The data indicated that ALSL is more effective than PM in counteracting obesity, insulin resistance, hyperlipidaemia, liver injury, and systemic inflammation in HFD-induced mice. These effects may be associated with the regulation of gut microbiota. ALSL significantly upregulated the abundance of Dubosiella, Lactobacillus, and Bifidobacterium while reducing the abundance of Ileibacterium. Furthermore, ALSL therapy increased the levels of acetic acid, propionic acid, and total short-chain fatty acids. Correlation analysis found that the positive changes in these gut microbes correlated positively with the anti-inflammatory, insulin-sensitizing, and anti-obesity effects of ALSL. |
| format | Article |
| id | doaj-art-c3b666f41756413c8f6e5cc867ad96a8 |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-c3b666f41756413c8f6e5cc867ad96a82025-01-05T12:47:43ZengNature Portfolionpj Science of Food2396-83702024-12-018111210.1038/s41538-024-00349-9Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet miceYing Huang0Wangxin Liu1Xianliang Luo2Minjie Zhao3Jing Wang4Sami Ullah5Wei Wei6Fengqin Feng7College of Biosystems Engineering and Food Science, Zhejiang UniversityCollege of Biosystems Engineering and Food Science, Zhejiang UniversityCollege of Food Science, Fujian Agriculture and Forestry UniversityCollege of Biosystems Engineering and Food Science, Zhejiang UniversityCollege of Biosystems Engineering and Food Science, Zhejiang UniversityCollege of Biosystems Engineering and Food Science, Zhejiang UniversityJiangsu Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan UniversityCollege of Biosystems Engineering and Food Science, Zhejiang UniversityAbstract Medium- and long-chain triacylglycerols (MLCTs) are regarded as healthy premium oils; however, the health benefits of novel MLCTs enriched with lauric and α-linolenic acids are still not fully understood. This study examined the health benefits of lauric-α-linolenic structural lipids (ALSL) and physical mixture (PM) with a similar fatty acid composition in mice with obesity induced by the high-fat diet (HFD). The data indicated that ALSL is more effective than PM in counteracting obesity, insulin resistance, hyperlipidaemia, liver injury, and systemic inflammation in HFD-induced mice. These effects may be associated with the regulation of gut microbiota. ALSL significantly upregulated the abundance of Dubosiella, Lactobacillus, and Bifidobacterium while reducing the abundance of Ileibacterium. Furthermore, ALSL therapy increased the levels of acetic acid, propionic acid, and total short-chain fatty acids. Correlation analysis found that the positive changes in these gut microbes correlated positively with the anti-inflammatory, insulin-sensitizing, and anti-obesity effects of ALSL.https://doi.org/10.1038/s41538-024-00349-9 |
| spellingShingle | Ying Huang Wangxin Liu Xianliang Luo Minjie Zhao Jing Wang Sami Ullah Wei Wei Fengqin Feng Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice npj Science of Food |
| title | Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice |
| title_full | Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice |
| title_fullStr | Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice |
| title_full_unstemmed | Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice |
| title_short | Lauric-α-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice |
| title_sort | lauric α linolenic lipids modulate gut microbiota preventing obesity insulin resistance and inflammation in high fat diet mice |
| url | https://doi.org/10.1038/s41538-024-00349-9 |
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