Influenza vaccine is able to induce post-infection antibodies to SARS-CoV-2 in medical staff
Influenza vaccination contributes to the favorable course and outcome of COVID-19. The aim of our study was to study the effect of influenza and pneumococcal vaccines on the level of IgG antibodies (AT) to SARS-CoV-2 among medical personnel at the beginning of the COVID-19 pandemic. We present the d...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2025-01-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/2982 |
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| author | M. P. Kostinov N. Yu. Nastaeva N. F. Nikityuk N. K. Akhmatova M. I. Albahansa S. V. Yushkova N. P. Andreeva A. M. Kostinova A. V. Linok M. N. Loktionova I. A. Khrapunova |
| author_facet | M. P. Kostinov N. Yu. Nastaeva N. F. Nikityuk N. K. Akhmatova M. I. Albahansa S. V. Yushkova N. P. Andreeva A. M. Kostinova A. V. Linok M. N. Loktionova I. A. Khrapunova |
| author_sort | M. P. Kostinov |
| collection | DOAJ |
| description | Influenza vaccination contributes to the favorable course and outcome of COVID-19. The aim of our study was to study the effect of influenza and pneumococcal vaccines on the level of IgG antibodies (AT) to SARS-CoV-2 among medical personnel at the beginning of the COVID-19 pandemic. We present the data on assessment of specific immune response to the influenza virus and SARS-CoV-2 in 266 medical workers 6 months after immunization against influenza and/or pneumococcal infection (without vaccinations against COVID-19) over the 2020-2021, by comparing the results with respective characteristic in 281 employees with no history of vaccinations is presented.We have found that the proportion of medical workers with a protective (≥ 1:40) antibody levels to influenza virus 6 months after vaccination in groups of participants reaches a protective (≥ 70%) value only in persons who received a monovaccine against pneumococcal infection (78.6%) as compared with persons vaccinated with a monovaccine against influenza (61.7%) (p < 0.001), as well as with a group of workers immunized against influenza in combination with the S. pneumoniae vaccine (68.9%) (p < 0.01). Hence, the pneumococcal vaccine is able to induce the synthesis of IgG-AT to influenza virus reaching protective values.An analysis of the group with seropositivity to influenza virus (IgG-AT ≥ 1:10) and their comparisons with persons seroprevalent to COVID-19 showed that the proportion of seropositive individuals among medical staff vaccinated against seasonal influenza after 6 months (indicating a probable asymptomatic form of COVID-19) is increased. It comprised 65.4% (p = 0.026) in the group vaccinated with mono-flu, and 64.5% (p = 0.04) in the group vaccinated with combined influenza and pneumococcus, being higher than among the non-immunized workers (48.8%).In summary, the results of our study show that influenza vaccination acts as an inducer of humoral immunity not only to the influenza virus, but also to the recently transmitted SARS-CoV-2 infection. |
| format | Article |
| id | doaj-art-c3a0fdfb312d4cb69456972fe51d8884 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2025-01-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-c3a0fdfb312d4cb69456972fe51d88842025-08-20T04:00:26ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2025-01-0127116917810.15789/1563-0625-IVI-29821980Influenza vaccine is able to induce post-infection antibodies to SARS-CoV-2 in medical staffM. P. Kostinov0N. Yu. Nastaeva1N. F. Nikityuk2N. K. Akhmatova3M. I. Albahansa4S. V. Yushkova5N. P. Andreeva6A. M. Kostinova7A. V. Linok8M. N. Loktionova9I. A. Khrapunova10I. Mechnikov Research Institute for Vaccines and Sera; I. Sechenov First Moscow State Medical University (Sechenov University)Novorossiysk Clinical Center, Federal Medical and Biological AgencyI. Mechnikov Research Institute for Vaccines and Sera; I. Sechenov First Moscow State Medical University (Sechenov University)I. Mechnikov Research Institute for Vaccines and SeraI. Sechenov First Moscow State Medical University (Sechenov University)I. Sechenov First Moscow State Medical University (Sechenov University)I. Ulyanov Chuvash State University; Сity Children’s Clinical Hospital of CheboksaryI. Sechenov First Moscow State Medical University (Sechenov University)I. Mechnikov Research Institute for Vaccines and Sera; I. Sechenov First Moscow State Medical University (Sechenov University)I. Sechenov First Moscow State Medical University (Sechenov University)I. Sechenov First Moscow State Medical University (Sechenov University)Influenza vaccination contributes to the favorable course and outcome of COVID-19. The aim of our study was to study the effect of influenza and pneumococcal vaccines on the level of IgG antibodies (AT) to SARS-CoV-2 among medical personnel at the beginning of the COVID-19 pandemic. We present the data on assessment of specific immune response to the influenza virus and SARS-CoV-2 in 266 medical workers 6 months after immunization against influenza and/or pneumococcal infection (without vaccinations against COVID-19) over the 2020-2021, by comparing the results with respective characteristic in 281 employees with no history of vaccinations is presented.We have found that the proportion of medical workers with a protective (≥ 1:40) antibody levels to influenza virus 6 months after vaccination in groups of participants reaches a protective (≥ 70%) value only in persons who received a monovaccine against pneumococcal infection (78.6%) as compared with persons vaccinated with a monovaccine against influenza (61.7%) (p < 0.001), as well as with a group of workers immunized against influenza in combination with the S. pneumoniae vaccine (68.9%) (p < 0.01). Hence, the pneumococcal vaccine is able to induce the synthesis of IgG-AT to influenza virus reaching protective values.An analysis of the group with seropositivity to influenza virus (IgG-AT ≥ 1:10) and their comparisons with persons seroprevalent to COVID-19 showed that the proportion of seropositive individuals among medical staff vaccinated against seasonal influenza after 6 months (indicating a probable asymptomatic form of COVID-19) is increased. It comprised 65.4% (p = 0.026) in the group vaccinated with mono-flu, and 64.5% (p = 0.04) in the group vaccinated with combined influenza and pneumococcus, being higher than among the non-immunized workers (48.8%).In summary, the results of our study show that influenza vaccination acts as an inducer of humoral immunity not only to the influenza virus, but also to the recently transmitted SARS-CoV-2 infection.https://www.mimmun.ru/mimmun/article/view/2982influenza immunitysars-cov-2 antibodiesvaccinationheterologous protectionadaptive immunitypandemic |
| spellingShingle | M. P. Kostinov N. Yu. Nastaeva N. F. Nikityuk N. K. Akhmatova M. I. Albahansa S. V. Yushkova N. P. Andreeva A. M. Kostinova A. V. Linok M. N. Loktionova I. A. Khrapunova Influenza vaccine is able to induce post-infection antibodies to SARS-CoV-2 in medical staff Медицинская иммунология influenza immunity sars-cov-2 antibodies vaccination heterologous protection adaptive immunity pandemic |
| title | Influenza vaccine is able to induce post-infection antibodies to SARS-CoV-2 in medical staff |
| title_full | Influenza vaccine is able to induce post-infection antibodies to SARS-CoV-2 in medical staff |
| title_fullStr | Influenza vaccine is able to induce post-infection antibodies to SARS-CoV-2 in medical staff |
| title_full_unstemmed | Influenza vaccine is able to induce post-infection antibodies to SARS-CoV-2 in medical staff |
| title_short | Influenza vaccine is able to induce post-infection antibodies to SARS-CoV-2 in medical staff |
| title_sort | influenza vaccine is able to induce post infection antibodies to sars cov 2 in medical staff |
| topic | influenza immunity sars-cov-2 antibodies vaccination heterologous protection adaptive immunity pandemic |
| url | https://www.mimmun.ru/mimmun/article/view/2982 |
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