Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with cronic myeloid leukemia treated with imatinib
Antioxidant status in patients with chronic myeloid leukemia (CML) is significantly decreased in comparison with healthy individuals. Oxidative stress (OS) may be associated with the pathophysiology of CML and can influence on development of resistance to imatinib. The aim of our study was to inve...
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| Format: | Article |
| Language: | English |
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University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association
2024-12-01
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| Series: | Makedonsko Farmacevtski Bilten |
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| Online Access: | https://bulletin.mfd.org.mk/volumes/Volume%2069_2/69_2_002.pdf |
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| author | Bojan Labachevski Dragica Zendelovska Marija Petrushevska Marija Popova-Labachevska Aleksandra Pivkova-Veljanovska Liljana Gjatovska-Labachevska Nevenka Ridova Sanja Trajkova Irina Panovska-Stavridis Trajan Balkanov |
| author_facet | Bojan Labachevski Dragica Zendelovska Marija Petrushevska Marija Popova-Labachevska Aleksandra Pivkova-Veljanovska Liljana Gjatovska-Labachevska Nevenka Ridova Sanja Trajkova Irina Panovska-Stavridis Trajan Balkanov |
| author_sort | Bojan Labachevski |
| collection | DOAJ |
| description | Antioxidant status in patients with chronic myeloid leukemia (CML) is significantly decreased in comparison with healthy individuals.
Oxidative stress (OS) may be associated with the pathophysiology of CML and can influence on development of resistance to imatinib.
The aim of our study was to investigate the effect of Aronia melanocarpa extract (A-lixir 400 PROTECT®) on OS in CML patients
treated with imatinib.
In this study a total of 40 CML patients treated with imatinib for longer than 1 month were included: twenty patients were treated with
imatinib and A-Lixir 400 PROTECT® (treatment group) and twenty patients were treated only with imatinib (control group). OS parameters
(d-ROM, PAT and OSI) were measured at the initial visit, and after 21 and 42 days of treatment. Adjuvant treatment with A-Lixir 400
PROTECT® could lead to attenuation of OS. d-ROM and OSI in this group of patients were significantly higher at initial visit when
compared to values after 21 and 42 days of treatment (p<0.05). Total antioxidant capacity (PAT) was significantly higher after 21 and 42
days of treatment initiation in comparison with the pretreatment values. In the control group no significant differences were obtained
between investigated parameters at any time of measurement. We can conclude that adjuvant treatment with A-Lixir 400 PROTECT® after
21 and 42 days lead to significant reduction of OS in patients with CML treated with imatinib. |
| format | Article |
| id | doaj-art-c38a62879b5f47a8923d2e5c18117948 |
| institution | Kabale University |
| issn | 1857-8969 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association |
| record_format | Article |
| series | Makedonsko Farmacevtski Bilten |
| spelling | doaj-art-c38a62879b5f47a8923d2e5c181179482025-01-11T12:38:17ZengUniversity Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical AssociationMakedonsko Farmacevtski Bilten1857-89692024-12-0169291710.33320/maced.pharm.bull.2023.69.02.002Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with cronic myeloid leukemia treated with imatinibBojan Labachevski0Dragica Zendelovska1Marija Petrushevska2Marija Popova-Labachevska3Aleksandra Pivkova-Veljanovska4Liljana Gjatovska-Labachevska5Nevenka Ridova6Sanja Trajkova7Irina Panovska-Stavridis8Trajan Balkanov9Institute of Preclinical and Clinical Pharmacology and Toxicology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, RN MacedoniaInstitute of Preclinical and Clinical Pharmacology and Toxicology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, RN MacedoniaInstitute of Preclinical and Clinical Pharmacology and Toxicology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, RN MacedoniaUniversity clinic of hematology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, RN MacedoniaUniversity clinic of hematology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, RN Macedonianstitute for Microbiology and Parasitology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, RN MacedoniaUniversity clinic of hematology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, RN MacedoniaUniversity clinic of hematology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, RN MacedoniaUniversity clinic of hematology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, RN MacedoniaInstitute of Preclinical and Clinical Pharmacology and Toxicology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, RN MacedoniaAntioxidant status in patients with chronic myeloid leukemia (CML) is significantly decreased in comparison with healthy individuals. Oxidative stress (OS) may be associated with the pathophysiology of CML and can influence on development of resistance to imatinib. The aim of our study was to investigate the effect of Aronia melanocarpa extract (A-lixir 400 PROTECT®) on OS in CML patients treated with imatinib. In this study a total of 40 CML patients treated with imatinib for longer than 1 month were included: twenty patients were treated with imatinib and A-Lixir 400 PROTECT® (treatment group) and twenty patients were treated only with imatinib (control group). OS parameters (d-ROM, PAT and OSI) were measured at the initial visit, and after 21 and 42 days of treatment. Adjuvant treatment with A-Lixir 400 PROTECT® could lead to attenuation of OS. d-ROM and OSI in this group of patients were significantly higher at initial visit when compared to values after 21 and 42 days of treatment (p<0.05). Total antioxidant capacity (PAT) was significantly higher after 21 and 42 days of treatment initiation in comparison with the pretreatment values. In the control group no significant differences were obtained between investigated parameters at any time of measurement. We can conclude that adjuvant treatment with A-Lixir 400 PROTECT® after 21 and 42 days lead to significant reduction of OS in patients with CML treated with imatinib.https://bulletin.mfd.org.mk/volumes/Volume%2069_2/69_2_002.pdfoxidative stressd-rompatosichronic myeloid leukemiaimatinibaronia melanocarpa |
| spellingShingle | Bojan Labachevski Dragica Zendelovska Marija Petrushevska Marija Popova-Labachevska Aleksandra Pivkova-Veljanovska Liljana Gjatovska-Labachevska Nevenka Ridova Sanja Trajkova Irina Panovska-Stavridis Trajan Balkanov Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with cronic myeloid leukemia treated with imatinib Makedonsko Farmacevtski Bilten oxidative stress d-rom pat osi chronic myeloid leukemia imatinib aronia melanocarpa |
| title | Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with cronic myeloid leukemia treated with imatinib |
| title_full | Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with cronic myeloid leukemia treated with imatinib |
| title_fullStr | Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with cronic myeloid leukemia treated with imatinib |
| title_full_unstemmed | Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with cronic myeloid leukemia treated with imatinib |
| title_short | Effect of standardized Aronia Melanocarpa extract on oxidative stress and antioxidant status in patient with cronic myeloid leukemia treated with imatinib |
| title_sort | effect of standardized aronia melanocarpa extract on oxidative stress and antioxidant status in patient with cronic myeloid leukemia treated with imatinib |
| topic | oxidative stress d-rom pat osi chronic myeloid leukemia imatinib aronia melanocarpa |
| url | https://bulletin.mfd.org.mk/volumes/Volume%2069_2/69_2_002.pdf |
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