Evaluation of nano-sized virgin coconut oil (VCO)-loaded liposomes for enhancing mushroom and B16-F10 tyrosinase activity
This study evaluated the potential impact of VCO-loaded liposomes, particularly on the activation of tyrosinase. Optimized liposomes containing 1 % (w/w) VCO were prepared using the film deposition on carrier method, resulting in a particle size of 84.02 ± 5.00 nm and a zeta potential of -68.40 ± 2....
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
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| Series: | OpenNano |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352952025000015 |
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| Summary: | This study evaluated the potential impact of VCO-loaded liposomes, particularly on the activation of tyrosinase. Optimized liposomes containing 1 % (w/w) VCO were prepared using the film deposition on carrier method, resulting in a particle size of 84.02 ± 5.00 nm and a zeta potential of -68.40 ± 2.78 mV. Encapsulation of VCO enhanced mushroom tyrosinase activity by 3-fold and exhibited lower cytotoxicity to B16-F10 cells compared to VCO alone. Moreover, a positive correlation was observed between the increase in intracellular tyrosinase activity and the concentrations of VCO (r = 0.8366) and VCO-loaded liposomes (r = 0.4794) in B16-F10 cells, while a negative correlation (r = -0.0545) was found for liposomes without VCO. A hair and eyebrow-darkening gel containing both VCO and VCO-loaded liposomes further enhanced mushroom tyrosinase activity by 283.33 ± 26.58 %. These findings suggest that VCO-loaded liposomes may serve as novel and effective nano-scale carriers for VCO in cosmetic applications. |
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| ISSN: | 2352-9520 |