Advances and challenges in neoantigen prediction for cancer immunotherapy

Advances and challenges in neoantigen prediction for cancer immunotherapy

Neoantigens, derived from tumor-specific mutations, are promising targets of cancer immunotherapy by eliciting tumor-specific T-cell responses while sparing normal cells. Accurate neoantigen prediction relies on immunogenomics and immunopeptidomics. Immunogenomics identifies tumor-specific mutations...

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Bibliographic Details
Main Authors: Yi Zhang, Ting-Ting Chen, Xiong Li, Ai-Lin Lan, Peng-Fei Ji, Ya-Juan Zhu, Xue-Yao Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
neoantigen prediction
cancer immunotherapy
next-generation sequencing
immunopeptidomics
bioinformatics
immune evasion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617654/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617654/full

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