The dose–response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise‐induced muscle damage in males
Abstract This study investigated the effects of two dosages (750 mg and 1500 mg) of hydrolyzed curcumin on physiological recovery following exercise‐induced muscle damage (EIMD). In a randomized, placebo‐controlled, double‐blind design, 34 recreationally active males (27 ± 6 years; 180 ± 7.3 cm; 82 ...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-08-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.70504 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849233927118520320 |
|---|---|
| author | Toby A. Helder Sean Condon Ian Grant Nathan A. Lewis Jessica Hill Charles R. Pedlar Luke Hughes |
| author_facet | Toby A. Helder Sean Condon Ian Grant Nathan A. Lewis Jessica Hill Charles R. Pedlar Luke Hughes |
| author_sort | Toby A. Helder |
| collection | DOAJ |
| description | Abstract This study investigated the effects of two dosages (750 mg and 1500 mg) of hydrolyzed curcumin on physiological recovery following exercise‐induced muscle damage (EIMD). In a randomized, placebo‐controlled, double‐blind design, 34 recreationally active males (27 ± 6 years; 180 ± 7.3 cm; 82 ± 11.3 kg) were assigned to three groups: PLA (2 × 750‐mg/day placebo), LOW (1 × 750‐mg/day curcumin + 1 × 750‐mg/day placebo), and HIGH (2 × 750‐mg/day curcumin). Supplements were delivered in 15 mL gel sachets over 7 days, starting 48 h before EIMD. The EIMD protocol involved 8 sets of 10 repetitions at 110% of one‐repetition maximum on the leg press, with 5‐s eccentric phases and assisted concentric phases, targeting the quadriceps. Recovery was assessed pre, post, 24, 48, and 72 h post‐EIMD via the Free Oxygen Radical Test (FORT), creatine kinase (CK), interleukin‐6 (IL‐6), isokinetic peak power, and a muscle endurance test (sustained isometric contraction at 50% peak torque). The HIGH group showed significantly greater reductions in pain, CK, FORT, and IL‐6 (p < 0.05), but slower muscle endurance recovery at 24 h compared to LOW. Findings suggest a dose–response effect, with higher curcumin doses improving biochemical recovery but potentially impairing performance recovery. |
| format | Article |
| id | doaj-art-c375c594dd1a4a2a996c29b9275c4d89 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-c375c594dd1a4a2a996c29b9275c4d892025-08-20T04:03:20ZengWileyPhysiological Reports2051-817X2025-08-011315n/an/a10.14814/phy2.70504The dose–response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise‐induced muscle damage in malesToby A. Helder0Sean Condon1Ian Grant2Nathan A. Lewis3Jessica Hill4Charles R. Pedlar5Luke Hughes6Faculty of Sport, Technology and Health Sciences St. Mary's University Twickenham London UKFaculty of Sport, Technology and Health Sciences St. Mary's University Twickenham London UKApplied and Human Sciences Kingston University London UKOrreco, Business Innovation Unit University of Galway Galway IrelandFaculty of Sport, Technology and Health Sciences St. Mary's University Twickenham London UKFaculty of Sport, Technology and Health Sciences St. Mary's University Twickenham London UKDepartment of Sport Exercise & Rehabilitation Northumbria University Newcastle upon Tyne UKAbstract This study investigated the effects of two dosages (750 mg and 1500 mg) of hydrolyzed curcumin on physiological recovery following exercise‐induced muscle damage (EIMD). In a randomized, placebo‐controlled, double‐blind design, 34 recreationally active males (27 ± 6 years; 180 ± 7.3 cm; 82 ± 11.3 kg) were assigned to three groups: PLA (2 × 750‐mg/day placebo), LOW (1 × 750‐mg/day curcumin + 1 × 750‐mg/day placebo), and HIGH (2 × 750‐mg/day curcumin). Supplements were delivered in 15 mL gel sachets over 7 days, starting 48 h before EIMD. The EIMD protocol involved 8 sets of 10 repetitions at 110% of one‐repetition maximum on the leg press, with 5‐s eccentric phases and assisted concentric phases, targeting the quadriceps. Recovery was assessed pre, post, 24, 48, and 72 h post‐EIMD via the Free Oxygen Radical Test (FORT), creatine kinase (CK), interleukin‐6 (IL‐6), isokinetic peak power, and a muscle endurance test (sustained isometric contraction at 50% peak torque). The HIGH group showed significantly greater reductions in pain, CK, FORT, and IL‐6 (p < 0.05), but slower muscle endurance recovery at 24 h compared to LOW. Findings suggest a dose–response effect, with higher curcumin doses improving biochemical recovery but potentially impairing performance recovery.https://doi.org/10.14814/phy2.70504antioxidantsdelayed onset muscle sorenesseccentric exerciseredoxturmeric |
| spellingShingle | Toby A. Helder Sean Condon Ian Grant Nathan A. Lewis Jessica Hill Charles R. Pedlar Luke Hughes The dose–response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise‐induced muscle damage in males Physiological Reports antioxidants delayed onset muscle soreness eccentric exercise redox turmeric |
| title | The dose–response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise‐induced muscle damage in males |
| title_full | The dose–response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise‐induced muscle damage in males |
| title_fullStr | The dose–response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise‐induced muscle damage in males |
| title_full_unstemmed | The dose–response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise‐induced muscle damage in males |
| title_short | The dose–response effects of hydrolyzed curcumin on recovery, inflammation, and oxidative stress following exercise‐induced muscle damage in males |
| title_sort | dose response effects of hydrolyzed curcumin on recovery inflammation and oxidative stress following exercise induced muscle damage in males |
| topic | antioxidants delayed onset muscle soreness eccentric exercise redox turmeric |
| url | https://doi.org/10.14814/phy2.70504 |
| work_keys_str_mv | AT tobyahelder thedoseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT seancondon thedoseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT iangrant thedoseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT nathanalewis thedoseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT jessicahill thedoseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT charlesrpedlar thedoseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT lukehughes thedoseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT tobyahelder doseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT seancondon doseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT iangrant doseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT nathanalewis doseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT jessicahill doseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT charlesrpedlar doseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales AT lukehughes doseresponseeffectsofhydrolyzedcurcuminonrecoveryinflammationandoxidativestressfollowingexerciseinducedmuscledamageinmales |