Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma
AimThis study aims to create and validate a novel systematic immune-inflammation-nutrition (SIIN) score to provide a non-invasive and accurate prognostic tool for head and neck squamous cell carcinoma (HNSCC) patients.Methods259 participants diagnosed with HNSCC from the First Affiliated Hospital of...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500525/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841540148059176960 |
|---|---|
| author | Wen-Yan Wang Yue Chen Qian Chen Hong-Wei Sun Nuo-Xuan Niu Hong-Hui Li Yu-Dan Cao Yan-Xia Bai Xiang Li Xiang Li |
| author_facet | Wen-Yan Wang Yue Chen Qian Chen Hong-Wei Sun Nuo-Xuan Niu Hong-Hui Li Yu-Dan Cao Yan-Xia Bai Xiang Li Xiang Li |
| author_sort | Wen-Yan Wang |
| collection | DOAJ |
| description | AimThis study aims to create and validate a novel systematic immune-inflammation-nutrition (SIIN) score to provide a non-invasive and accurate prognostic tool for head and neck squamous cell carcinoma (HNSCC) patients.Methods259 participants diagnosed with HNSCC from the First Affiliated Hospital of Xi’an Jiaotong University between 2008 and 2017 was included in this retrospective study. Patients were assigned to training (n=181) and validation (n=78) sets. A LASSO Cox regression model was employed to identify significant biomarkers for constructing a SIIN nomogram and to create SIIN score from this nomogram. The prognostic accuracy of the SIIN score was assessed by exploiting receiver operating characteristic (ROC) analysis, Kaplan-Meier survival analysis, Cox proportional hazard regression models, calibration and DCA curves.ResultsThe SIIN score was formulated based on six biomarkers-platelet-lymphocyte ratio (PLR), prognostic nutritional index (PNI), systemic immune-inflammation index (SII), albumin-bilirubin index (ALBI), fibrinogen (FIB) and monocyte count-identified by LASSO regression analysis. (1)The SIIN score demonstrated superior predictive value, achieving area under the ROC curve (AUC) values of 0.736 and 0.700 for 3- and 5-year OS. For recurrence-free survival (RFS), the AUC values were 0.752 for 3-year and 0.701 5-year RFS, as assessed in the training set. Validated as an independent prognostic factor in both cohorts, the SIIN score showed strong correlation with adverse clinicopathological outcomes.ConclusionThe SIIN score is a promising prognostic tool that integrates immune, inflammatory, and nutritional factors for predicting clinical outcomes in HNSCC patients. It offers enhanced predictive accuracy compared to existing markers and has the potential to guide personalized treatment strategies and clinical decision-making. |
| format | Article |
| id | doaj-art-c35b6e56bc7b4d3b88ab9cbfea4b86c1 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c35b6e56bc7b4d3b88ab9cbfea4b86c12025-01-14T06:10:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15005251500525Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinomaWen-Yan Wang0Yue Chen1Qian Chen2Hong-Wei Sun3Nuo-Xuan Niu4Hong-Hui Li5Yu-Dan Cao6Yan-Xia Bai7Xiang Li8Xiang Li9Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaCenter for Gut Microbiome Research, Med-X Institute Centre, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaCenter for Gut Microbiome Research, Med-X Institute Centre, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaAimThis study aims to create and validate a novel systematic immune-inflammation-nutrition (SIIN) score to provide a non-invasive and accurate prognostic tool for head and neck squamous cell carcinoma (HNSCC) patients.Methods259 participants diagnosed with HNSCC from the First Affiliated Hospital of Xi’an Jiaotong University between 2008 and 2017 was included in this retrospective study. Patients were assigned to training (n=181) and validation (n=78) sets. A LASSO Cox regression model was employed to identify significant biomarkers for constructing a SIIN nomogram and to create SIIN score from this nomogram. The prognostic accuracy of the SIIN score was assessed by exploiting receiver operating characteristic (ROC) analysis, Kaplan-Meier survival analysis, Cox proportional hazard regression models, calibration and DCA curves.ResultsThe SIIN score was formulated based on six biomarkers-platelet-lymphocyte ratio (PLR), prognostic nutritional index (PNI), systemic immune-inflammation index (SII), albumin-bilirubin index (ALBI), fibrinogen (FIB) and monocyte count-identified by LASSO regression analysis. (1)The SIIN score demonstrated superior predictive value, achieving area under the ROC curve (AUC) values of 0.736 and 0.700 for 3- and 5-year OS. For recurrence-free survival (RFS), the AUC values were 0.752 for 3-year and 0.701 5-year RFS, as assessed in the training set. Validated as an independent prognostic factor in both cohorts, the SIIN score showed strong correlation with adverse clinicopathological outcomes.ConclusionThe SIIN score is a promising prognostic tool that integrates immune, inflammatory, and nutritional factors for predicting clinical outcomes in HNSCC patients. It offers enhanced predictive accuracy compared to existing markers and has the potential to guide personalized treatment strategies and clinical decision-making.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500525/fullnomogramimmune-inflammation-nutrition scoreprognostichead and neck squamous cell carcinomaindicator |
| spellingShingle | Wen-Yan Wang Yue Chen Qian Chen Hong-Wei Sun Nuo-Xuan Niu Hong-Hui Li Yu-Dan Cao Yan-Xia Bai Xiang Li Xiang Li Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma Frontiers in Immunology nomogram immune-inflammation-nutrition score prognostic head and neck squamous cell carcinoma indicator |
| title | Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma |
| title_full | Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma |
| title_fullStr | Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma |
| title_full_unstemmed | Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma |
| title_short | Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma |
| title_sort | nomogram derived immune inflammation nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma |
| topic | nomogram immune-inflammation-nutrition score prognostic head and neck squamous cell carcinoma indicator |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500525/full |
| work_keys_str_mv | AT wenyanwang nomogramderivedimmuneinflammationnutritionscorecouldactasanovelprognosticindicatorforpatientswithheadandnecksquamouscellcarcinoma AT yuechen nomogramderivedimmuneinflammationnutritionscorecouldactasanovelprognosticindicatorforpatientswithheadandnecksquamouscellcarcinoma AT qianchen nomogramderivedimmuneinflammationnutritionscorecouldactasanovelprognosticindicatorforpatientswithheadandnecksquamouscellcarcinoma AT hongweisun nomogramderivedimmuneinflammationnutritionscorecouldactasanovelprognosticindicatorforpatientswithheadandnecksquamouscellcarcinoma AT nuoxuanniu nomogramderivedimmuneinflammationnutritionscorecouldactasanovelprognosticindicatorforpatientswithheadandnecksquamouscellcarcinoma AT honghuili nomogramderivedimmuneinflammationnutritionscorecouldactasanovelprognosticindicatorforpatientswithheadandnecksquamouscellcarcinoma AT yudancao nomogramderivedimmuneinflammationnutritionscorecouldactasanovelprognosticindicatorforpatientswithheadandnecksquamouscellcarcinoma AT yanxiabai nomogramderivedimmuneinflammationnutritionscorecouldactasanovelprognosticindicatorforpatientswithheadandnecksquamouscellcarcinoma AT xiangli nomogramderivedimmuneinflammationnutritionscorecouldactasanovelprognosticindicatorforpatientswithheadandnecksquamouscellcarcinoma AT xiangli nomogramderivedimmuneinflammationnutritionscorecouldactasanovelprognosticindicatorforpatientswithheadandnecksquamouscellcarcinoma |