Novel introductions of human-origin H3N2 influenza viruses in swine, Chile
Influenza A virus (IAV) continuously threatens animal and public health globally, with swine serving as a crucial reservoir for viral reassortment and evolution. In Chile, H1N2 and H3N2 subtypes were introduced in the swine population before the H1N1 2009 pandemic, and the H1N1 was introduced from t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1505497/full |
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| author | Belen Monserrat Agüero Naomi Ariyama Felipe Berrios Nikita Enciso Barbara Quezada Rafael A. Medina Rafael A. Medina Victor Neira Victor Neira |
| author_facet | Belen Monserrat Agüero Naomi Ariyama Felipe Berrios Nikita Enciso Barbara Quezada Rafael A. Medina Rafael A. Medina Victor Neira Victor Neira |
| author_sort | Belen Monserrat Agüero |
| collection | DOAJ |
| description | Influenza A virus (IAV) continuously threatens animal and public health globally, with swine serving as a crucial reservoir for viral reassortment and evolution. In Chile, H1N2 and H3N2 subtypes were introduced in the swine population before the H1N1 2009 pandemic, and the H1N1 was introduced from the H1N1pdm09 by successive reverse zoonotic events. Here, we report two novel introductions of IAV H3N2 human-origin in Chilean swine during 2023. Our study reveals a closer relationship between recent human seasonal H3N2 and novel swine strains. Interestingly, one strain maintains all the genes from the original human virus, but the other strain is already a reassortment of human H3N2 and an H1N2 previously observed on the farm. Observing global IAV sequences, a similar pattern was identified in the USA confirming the reverse zoonotic potential of current seasonal human H3N2 strains. These results highlight the importance of ongoing surveillance and reinforcing biosecurity in swine farms. These findings raise questions about their potential impact on viral dynamics in the swine population and public health, underscoring the need for further investigation into the origin and evolutionary dynamics of this emerging swine H3N2 reassortant virus. |
| format | Article |
| id | doaj-art-c3422bec8c4a4886bf964eb9e66c1183 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-c3422bec8c4a4886bf964eb9e66c11832025-01-09T14:43:47ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.15054971505497Novel introductions of human-origin H3N2 influenza viruses in swine, ChileBelen Monserrat Agüero0Naomi Ariyama1Felipe Berrios2Nikita Enciso3Barbara Quezada4Rafael A. Medina5Rafael A. Medina6Victor Neira7Victor Neira8Departamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, ChileDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, ChileDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, ChileDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, ChileDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, ChileDepartment of Pathology and Laboratory Medicine, School of Medicine, Emory Vaccine Center, Emory University, Atlanta, GA, United StatesCenter for Research on Influenza Pathogenesis and Transmission (CRIPT), Center of Excellence of Influenza Research and Response (CEIRR), New York, NY, United StatesDepartamento de Medicina Preventiva Animal, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, ChileCenter for Research on Influenza Pathogenesis and Transmission (CRIPT), Center of Excellence of Influenza Research and Response (CEIRR), New York, NY, United StatesInfluenza A virus (IAV) continuously threatens animal and public health globally, with swine serving as a crucial reservoir for viral reassortment and evolution. In Chile, H1N2 and H3N2 subtypes were introduced in the swine population before the H1N1 2009 pandemic, and the H1N1 was introduced from the H1N1pdm09 by successive reverse zoonotic events. Here, we report two novel introductions of IAV H3N2 human-origin in Chilean swine during 2023. Our study reveals a closer relationship between recent human seasonal H3N2 and novel swine strains. Interestingly, one strain maintains all the genes from the original human virus, but the other strain is already a reassortment of human H3N2 and an H1N2 previously observed on the farm. Observing global IAV sequences, a similar pattern was identified in the USA confirming the reverse zoonotic potential of current seasonal human H3N2 strains. These results highlight the importance of ongoing surveillance and reinforcing biosecurity in swine farms. These findings raise questions about their potential impact on viral dynamics in the swine population and public health, underscoring the need for further investigation into the origin and evolutionary dynamics of this emerging swine H3N2 reassortant virus.https://www.frontiersin.org/articles/10.3389/fvets.2024.1505497/fullinfluenza A virusswinezoonosispigsurveillance |
| spellingShingle | Belen Monserrat Agüero Naomi Ariyama Felipe Berrios Nikita Enciso Barbara Quezada Rafael A. Medina Rafael A. Medina Victor Neira Victor Neira Novel introductions of human-origin H3N2 influenza viruses in swine, Chile Frontiers in Veterinary Science influenza A virus swine zoonosis pig surveillance |
| title | Novel introductions of human-origin H3N2 influenza viruses in swine, Chile |
| title_full | Novel introductions of human-origin H3N2 influenza viruses in swine, Chile |
| title_fullStr | Novel introductions of human-origin H3N2 influenza viruses in swine, Chile |
| title_full_unstemmed | Novel introductions of human-origin H3N2 influenza viruses in swine, Chile |
| title_short | Novel introductions of human-origin H3N2 influenza viruses in swine, Chile |
| title_sort | novel introductions of human origin h3n2 influenza viruses in swine chile |
| topic | influenza A virus swine zoonosis pig surveillance |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1505497/full |
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