How to target vascular leakage in retinopathy: could a lipid tighten the pipes?
Abstract Retinopathy is one of the more severe complications associated with diabetes. Targeting vascular pathology has shown benefits, but current therapies are costly and have limitations. In this issue of EMBO Molecular Medicine, Niaudet et al report that the activation of the S1PR1 receptor in e...
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| Format: | Article |
| Language: | English |
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Springer Nature
2023-03-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.202317520 |
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| _version_ | 1846171768038883328 |
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| author | M Luisa Iruela‐Arispe |
| author_facet | M Luisa Iruela‐Arispe |
| author_sort | M Luisa Iruela‐Arispe |
| collection | DOAJ |
| description | Abstract Retinopathy is one of the more severe complications associated with diabetes. Targeting vascular pathology has shown benefits, but current therapies are costly and have limitations. In this issue of EMBO Molecular Medicine, Niaudet et al report that the activation of the S1PR1 receptor in endothelial cells is able to block abnormal permeability, neovascular tuft development, and resolve pathological vascular lesions associated with hypoxia‐driven retinopathy. |
| format | Article |
| id | doaj-art-c33fd922d10a4055b141df60fc298fb3 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-c33fd922d10a4055b141df60fc298fb32024-11-10T12:37:42ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842023-03-011551310.15252/emmm.202317520How to target vascular leakage in retinopathy: could a lipid tighten the pipes?M Luisa Iruela‐Arispe0Department of Cell and Development Biology, Feinberg School of Medicine, Northwestern UniversityAbstract Retinopathy is one of the more severe complications associated with diabetes. Targeting vascular pathology has shown benefits, but current therapies are costly and have limitations. In this issue of EMBO Molecular Medicine, Niaudet et al report that the activation of the S1PR1 receptor in endothelial cells is able to block abnormal permeability, neovascular tuft development, and resolve pathological vascular lesions associated with hypoxia‐driven retinopathy.https://doi.org/10.15252/emmm.202317520 |
| spellingShingle | M Luisa Iruela‐Arispe How to target vascular leakage in retinopathy: could a lipid tighten the pipes? EMBO Molecular Medicine |
| title | How to target vascular leakage in retinopathy: could a lipid tighten the pipes? |
| title_full | How to target vascular leakage in retinopathy: could a lipid tighten the pipes? |
| title_fullStr | How to target vascular leakage in retinopathy: could a lipid tighten the pipes? |
| title_full_unstemmed | How to target vascular leakage in retinopathy: could a lipid tighten the pipes? |
| title_short | How to target vascular leakage in retinopathy: could a lipid tighten the pipes? |
| title_sort | how to target vascular leakage in retinopathy could a lipid tighten the pipes |
| url | https://doi.org/10.15252/emmm.202317520 |
| work_keys_str_mv | AT mluisairuelaarispe howtotargetvascularleakageinretinopathycouldalipidtightenthepipes |