The pathogenesis of adenomyosis and its impact on fertility: a literature review
Adenomyosis, an ingrowth of endometrial tissue into the uterine wall, is a benign gynecological disease associated with infertility, pelvic pain, and abnormal uterine bleeding, having serious consequences for a woman's health and quality of life. Diagnosis of adenomyosis is often challenging du...
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| Language: | Russian |
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Kemerovo State Medical University
2024-09-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/908 |
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| author | V. V. Likhacheva O. V. Azarova L. V. Renge P. Yu. Motyreva N. A. Khonina B. I. Ayzikovich |
| author_facet | V. V. Likhacheva O. V. Azarova L. V. Renge P. Yu. Motyreva N. A. Khonina B. I. Ayzikovich |
| author_sort | V. V. Likhacheva |
| collection | DOAJ |
| description | Adenomyosis, an ingrowth of endometrial tissue into the uterine wall, is a benign gynecological disease associated with infertility, pelvic pain, and abnormal uterine bleeding, having serious consequences for a woman's health and quality of life. Diagnosis of adenomyosis is often challenging due to the concomitant endometrial hyperplasia. The pathogenesis of adenomyosis has not yet been fully evaluated and requires further fundamental and clinical research. Here we analyze an impact of local and systemic immunity on the development and progression of adenomyosis. Several studies highlight the role of immune cell activation and excessive release of both proinflammatory and anti-inflammatory cytokines. Women with adenomyosis exhibit an imbalance in the interferon system, elevated levels of certain growth factors, defensins, and chemokines. Immune system disorders well correlate with the clinical symptoms of adenomyosis and entail adverse consequences for the female reproductive system. Oxidative stress that occurs in adenomyosis leads to an excess of free radicals that can damage the embryo. Alterations in cell adhesion levels prevent implantation, and morphological changes in the myometrium lead to a violation of its peristalsis and impede the sperm transport. Changes in the cytokine profile and the levels of transport proteins in women with adenomyosis may serve as predictors of the assisted reproductive technology outcomes. This review discusses the recent literature on adenomyosis and its impact on women reproductive function. |
| format | Article |
| id | doaj-art-c33f64eee3f3415b878cbf3c6a6cfc4d |
| institution | Kabale University |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2024-09-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-c33f64eee3f3415b878cbf3c6a6cfc4d2025-08-20T03:57:40ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412024-09-019313013910.23946/2500-0764-2024-9-3-130-139447The pathogenesis of adenomyosis and its impact on fertility: a literature reviewV. V. Likhacheva0O. V. Azarova1L. V. Renge2P. Yu. Motyreva3N. A. Khonina4B. I. Ayzikovich5Novokuznetsk State Institute for Postgraduate Medical Education – Branch of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian FederationMedical Center "Expert"Novokuznetsk State Institute for Postgraduate Medical Education – Branch of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian FederationMedical Center "Avicenna"Research Institute of Fundamental and Clinical ImmunologyNovosibirsk National Research State UniversityAdenomyosis, an ingrowth of endometrial tissue into the uterine wall, is a benign gynecological disease associated with infertility, pelvic pain, and abnormal uterine bleeding, having serious consequences for a woman's health and quality of life. Diagnosis of adenomyosis is often challenging due to the concomitant endometrial hyperplasia. The pathogenesis of adenomyosis has not yet been fully evaluated and requires further fundamental and clinical research. Here we analyze an impact of local and systemic immunity on the development and progression of adenomyosis. Several studies highlight the role of immune cell activation and excessive release of both proinflammatory and anti-inflammatory cytokines. Women with adenomyosis exhibit an imbalance in the interferon system, elevated levels of certain growth factors, defensins, and chemokines. Immune system disorders well correlate with the clinical symptoms of adenomyosis and entail adverse consequences for the female reproductive system. Oxidative stress that occurs in adenomyosis leads to an excess of free radicals that can damage the embryo. Alterations in cell adhesion levels prevent implantation, and morphological changes in the myometrium lead to a violation of its peristalsis and impede the sperm transport. Changes in the cytokine profile and the levels of transport proteins in women with adenomyosis may serve as predictors of the assisted reproductive technology outcomes. This review discusses the recent literature on adenomyosis and its impact on women reproductive function.https://fcm.kemsmu.ru/jour/article/view/908adenomyosisinfertilitymiscarriageinflammationimmunityin vitro fertilization |
| spellingShingle | V. V. Likhacheva O. V. Azarova L. V. Renge P. Yu. Motyreva N. A. Khonina B. I. Ayzikovich The pathogenesis of adenomyosis and its impact on fertility: a literature review Фундаментальная и клиническая медицина adenomyosis infertility miscarriage inflammation immunity in vitro fertilization |
| title | The pathogenesis of adenomyosis and its impact on fertility: a literature review |
| title_full | The pathogenesis of adenomyosis and its impact on fertility: a literature review |
| title_fullStr | The pathogenesis of adenomyosis and its impact on fertility: a literature review |
| title_full_unstemmed | The pathogenesis of adenomyosis and its impact on fertility: a literature review |
| title_short | The pathogenesis of adenomyosis and its impact on fertility: a literature review |
| title_sort | pathogenesis of adenomyosis and its impact on fertility a literature review |
| topic | adenomyosis infertility miscarriage inflammation immunity in vitro fertilization |
| url | https://fcm.kemsmu.ru/jour/article/view/908 |
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