Mucormycosis in children with hematological and oncological diseases in saint-petersburg

Mucormycosis in children with hematological and oncological diseases in saint-petersburg

In prospective multicenter study were included 20 pediatriconcohematologic patients with mucormycosis. Age: 3 – 17 yy (median – 11), females – 60%. The diagnosiswas made according to EORTC/MSG 2008 criteria (post mortem – 25%). The main underlying disease was acutel eukemia (70%), risk factors – pro...

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Main Authors: N. N. Klimko, S. N. Khostelidi, E. G. Boychenko, A. S. Kolbin, A. G. Volkova, M. O. Popova, T. S. Bogomolova, L. S. Zuborovskaya, M. B. Belogurova, N. V. Medvedeva, B. V. Afanasyev
Format: Article
Language:Russian
Published: Journal Infectology 2016-11-01
Series:Журнал инфектологии
Subjects:
mucormycosis
acute leukemia
lichtheimia corуmbifera
rhizopus
rhizomucor
amphotericin b lipid complex
posaconazole
Online Access:https://journal.niidi.ru/jofin/article/view/508
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Summary:In prospective multicenter study were included 20 pediatriconcohematologic patients with mucormycosis. Age: 3 – 17 yy (median – 11), females – 60%. The diagnosiswas made according to EORTC/MSG 2008 criteria (post mortem – 25%). The main underlying disease was acutel eukemia (70%), risk factors – prolong severe neutropenia (median – 31 d) and lymphocytopenia (median – 33 d) after cytostatic chemotherapy or hematopoietic stem cells transplantation. Etiology agents were Lichtheimia corуmbifera, Rhizopus spp. and Rhizomucor spp. Main sites of infection were lungs (65%) and paranasal synuses (30%), dissemination – 45%. Antifungal therapy (amphotericin B lipid coplex, posaconazole, caspofungin, amphotericin B) was used in 75% patients, surgery – 30%. Overall mortality in 12 weeks was 70%.
ISSN:2072-6732

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