Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's disease
Abstract INTRODUCTION This study investigated the changes in functional capacity with disease progression in a well‐characterised cohort of patients diagnosed with frontotemporal dementia (FTD) and Alzheimer's disease (AD) presentations. METHODS We recruited 126 behavioural variant FTD (bvFTD),...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-10-01
|
| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.70028 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846106514371117056 |
|---|---|
| author | David Foxe Muireann Irish Sau Chi Cheung Mirelle D'Mello Yun Tae Hwang James Muggleton Nicholas J. Cordato Olivier Piguet |
| author_facet | David Foxe Muireann Irish Sau Chi Cheung Mirelle D'Mello Yun Tae Hwang James Muggleton Nicholas J. Cordato Olivier Piguet |
| author_sort | David Foxe |
| collection | DOAJ |
| description | Abstract INTRODUCTION This study investigated the changes in functional capacity with disease progression in a well‐characterised cohort of patients diagnosed with frontotemporal dementia (FTD) and Alzheimer's disease (AD) presentations. METHODS We recruited 126 behavioural variant FTD (bvFTD), 40 progressive nonfluent aphasia (PNFA), 64 semantic dementia (SD), 45 logopenic progressive aphasia (LPA), and 115 AD patients. Functional capacity was measured annually over ∼7 years using the Disability Assessment for Dementia. RESULTS Linear mixed effects models revealed the bvFTD group demonstrated disproportionate functional impairment at baseline and over the study period. Functional capacity among the other syndromes showed a more uniform pattern of decline, with less severe functional impairment at baseline and ∼7%–10% mean annual decline. Baseline correlations indicated different mechanisms supporting basic and complex functional proficiency among the groups. DISCUSSION Our findings demonstrate distinct functional profiles across dementia syndromes with disease progression. Identifying progression milestones across syndromes will improve clinical management. Highlights bvFTD shows severe functional impairment at baseline and over time. PNFA, SD, LPA, AD: less severe baseline functional impairment; more uniform decline. General cognition is related to IADLs, but not BADLs, in all groups. Behavioural disturbances relate to IADLs and BADLs in bvFTD and SD. Behavioural‐ADL relations are more mixed in PNFA, LPA, and AD. |
| format | Article |
| id | doaj-art-c2f8874545924f6eaec6e9a9a19fd294 |
| institution | Kabale University |
| issn | 2352-8729 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-c2f8874545924f6eaec6e9a9a19fd2942024-12-27T13:08:30ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292024-10-01164n/an/a10.1002/dad2.70028Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's diseaseDavid Foxe0Muireann Irish1Sau Chi Cheung2Mirelle D'Mello3Yun Tae Hwang4James Muggleton5Nicholas J. Cordato6Olivier Piguet7The University of Sydney School of Psychology Sydney AustraliaThe University of Sydney School of Psychology Sydney AustraliaThe University of Sydney School of Psychology Sydney AustraliaThe University of Sydney School of Psychology Sydney AustraliaThe University of Sydney Brain and Mind Centre Sydney AustraliaPrince of Wales Hospital Department of Aged Care Sydney AustraliaThe University of Sydney Brain and Mind Centre Sydney AustraliaThe University of Sydney School of Psychology Sydney AustraliaAbstract INTRODUCTION This study investigated the changes in functional capacity with disease progression in a well‐characterised cohort of patients diagnosed with frontotemporal dementia (FTD) and Alzheimer's disease (AD) presentations. METHODS We recruited 126 behavioural variant FTD (bvFTD), 40 progressive nonfluent aphasia (PNFA), 64 semantic dementia (SD), 45 logopenic progressive aphasia (LPA), and 115 AD patients. Functional capacity was measured annually over ∼7 years using the Disability Assessment for Dementia. RESULTS Linear mixed effects models revealed the bvFTD group demonstrated disproportionate functional impairment at baseline and over the study period. Functional capacity among the other syndromes showed a more uniform pattern of decline, with less severe functional impairment at baseline and ∼7%–10% mean annual decline. Baseline correlations indicated different mechanisms supporting basic and complex functional proficiency among the groups. DISCUSSION Our findings demonstrate distinct functional profiles across dementia syndromes with disease progression. Identifying progression milestones across syndromes will improve clinical management. Highlights bvFTD shows severe functional impairment at baseline and over time. PNFA, SD, LPA, AD: less severe baseline functional impairment; more uniform decline. General cognition is related to IADLs, but not BADLs, in all groups. Behavioural disturbances relate to IADLs and BADLs in bvFTD and SD. Behavioural‐ADL relations are more mixed in PNFA, LPA, and AD.https://doi.org/10.1002/dad2.70028activities of daily livingAlzheimer's diseasefrontotemporal dementialongitudinal assessmentprimary progressive aphasia |
| spellingShingle | David Foxe Muireann Irish Sau Chi Cheung Mirelle D'Mello Yun Tae Hwang James Muggleton Nicholas J. Cordato Olivier Piguet Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's disease Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring activities of daily living Alzheimer's disease frontotemporal dementia longitudinal assessment primary progressive aphasia |
| title | Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's disease |
| title_full | Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's disease |
| title_fullStr | Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's disease |
| title_full_unstemmed | Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's disease |
| title_short | Longitudinal changes in functional capacity in frontotemporal dementia and Alzheimer's disease |
| title_sort | longitudinal changes in functional capacity in frontotemporal dementia and alzheimer s disease |
| topic | activities of daily living Alzheimer's disease frontotemporal dementia longitudinal assessment primary progressive aphasia |
| url | https://doi.org/10.1002/dad2.70028 |
| work_keys_str_mv | AT davidfoxe longitudinalchangesinfunctionalcapacityinfrontotemporaldementiaandalzheimersdisease AT muireannirish longitudinalchangesinfunctionalcapacityinfrontotemporaldementiaandalzheimersdisease AT sauchicheung longitudinalchangesinfunctionalcapacityinfrontotemporaldementiaandalzheimersdisease AT mirelledmello longitudinalchangesinfunctionalcapacityinfrontotemporaldementiaandalzheimersdisease AT yuntaehwang longitudinalchangesinfunctionalcapacityinfrontotemporaldementiaandalzheimersdisease AT jamesmuggleton longitudinalchangesinfunctionalcapacityinfrontotemporaldementiaandalzheimersdisease AT nicholasjcordato longitudinalchangesinfunctionalcapacityinfrontotemporaldementiaandalzheimersdisease AT olivierpiguet longitudinalchangesinfunctionalcapacityinfrontotemporaldementiaandalzheimersdisease |