Novel Antibacterial 4-Piperazinylquinoline Hybrid Derivatives Against <i>Staphylococcus aureus</i>: Design, Synthesis, and In Vitro and In Silico Insights

Novel Antibacterial 4-Piperazinylquinoline Hybrid Derivatives Against <i>Staphylococcus aureus</i>: Design, Synthesis, and In Vitro and In Silico Insights

Molecular hybridization, which consists of the combination of two or more pharmacophores into a single molecule, is an innovative approach in drug design to afford new chemical entities with enhanced biological activity. In the present study, this strategy was pursued to develop a new series of 6,7-...

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Bibliographic Details
Main Authors: Gabriele La Monica, Annamaria Gallo, Alessia Bono, Federica Alamia, Antonino Lauria, Rosa Alduina, Annamaria Martorana
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
molecular hybridization
quinoline
piperazine
<i>Staphylococcus aureus</i>
antibiotic activity
heterocyclic compounds
Online Access:https://www.mdpi.com/1420-3049/30/1/28
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