Familial hypercholesterolemia mimicking juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA) seen in children is a diagnosis of exclusion, as many systemic and metabolic diseases have similar presentation. Here, we present a case of a 14-year-old female girl who presented with polyarthralgia, fever, and nodules over body. She was diagnosed as JIA initiall...
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SAGE Publishing
2022-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=1;spage=78;epage=81;aulast=Dhaon |
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| author | Pooja Dhaon Utkarsh Bansal Dileep Jain |
| author_facet | Pooja Dhaon Utkarsh Bansal Dileep Jain |
| author_sort | Pooja Dhaon |
| collection | DOAJ |
| description | Juvenile idiopathic arthritis (JIA) seen in children is a diagnosis of exclusion, as many systemic and metabolic diseases have similar presentation. Here, we present a case of a 14-year-old female girl who presented with polyarthralgia, fever, and nodules over body. She was diagnosed as JIA initially without any response to treatment. On further assessment, she had xanthelasma on eyelids, and a very high and low-density lipoprotein-cholesterol, a second-degree relative also with similar findings. The histopathology of the nodule was suggestive of xanthoma. Thus, she was diagnosed as familial hypercholesterolemia (FH) and was given statins. Articular manifestations are not very uncommon in patients of FH, and sometimes, they are the presenting symptoms in these patients. There are number of causes of arthritis with subcutaneous nodules in children apart from JIA which have been enumerated. Thus, FH must also be considered as a differential diagnosis in such patients. |
| format | Article |
| id | doaj-art-c2d938b15e3243e3ae4cdfecbdabf5c8 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-c2d938b15e3243e3ae4cdfecbdabf5c82025-01-02T04:57:27ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012022-01-01171788110.4103/injr.injr_22_21Familial hypercholesterolemia mimicking juvenile idiopathic arthritisPooja DhaonUtkarsh BansalDileep JainJuvenile idiopathic arthritis (JIA) seen in children is a diagnosis of exclusion, as many systemic and metabolic diseases have similar presentation. Here, we present a case of a 14-year-old female girl who presented with polyarthralgia, fever, and nodules over body. She was diagnosed as JIA initially without any response to treatment. On further assessment, she had xanthelasma on eyelids, and a very high and low-density lipoprotein-cholesterol, a second-degree relative also with similar findings. The histopathology of the nodule was suggestive of xanthoma. Thus, she was diagnosed as familial hypercholesterolemia (FH) and was given statins. Articular manifestations are not very uncommon in patients of FH, and sometimes, they are the presenting symptoms in these patients. There are number of causes of arthritis with subcutaneous nodules in children apart from JIA which have been enumerated. Thus, FH must also be considered as a differential diagnosis in such patients.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=1;spage=78;epage=81;aulast=Dhaonfamilial hypercholesterolemiajuvenile idiopathic arthritisxanthelasmaxanthoma |
| spellingShingle | Pooja Dhaon Utkarsh Bansal Dileep Jain Familial hypercholesterolemia mimicking juvenile idiopathic arthritis Indian Journal of Rheumatology familial hypercholesterolemia juvenile idiopathic arthritis xanthelasma xanthoma |
| title | Familial hypercholesterolemia mimicking juvenile idiopathic arthritis |
| title_full | Familial hypercholesterolemia mimicking juvenile idiopathic arthritis |
| title_fullStr | Familial hypercholesterolemia mimicking juvenile idiopathic arthritis |
| title_full_unstemmed | Familial hypercholesterolemia mimicking juvenile idiopathic arthritis |
| title_short | Familial hypercholesterolemia mimicking juvenile idiopathic arthritis |
| title_sort | familial hypercholesterolemia mimicking juvenile idiopathic arthritis |
| topic | familial hypercholesterolemia juvenile idiopathic arthritis xanthelasma xanthoma |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=1;spage=78;epage=81;aulast=Dhaon |
| work_keys_str_mv | AT poojadhaon familialhypercholesterolemiamimickingjuvenileidiopathicarthritis AT utkarshbansal familialhypercholesterolemiamimickingjuvenileidiopathicarthritis AT dileepjain familialhypercholesterolemiamimickingjuvenileidiopathicarthritis |