Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma
ATM and γH2AX play a vital role in the detection of DNA double-strand breaks (DSB) and DNA damage response (DDR). This study aims to investigate ATM and γH2AX expression in thyroid cancer and discuss possible relationship between thyroid function tests and DNA damage. The expression of ATM and γH2AX...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/136810 |
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| author | Jin-lin Hu Si-si Hu Xiu-xiu Hou Xin Zhu Jun Cao Lie-hao Jiang Ming-hua Ge |
| author_facet | Jin-lin Hu Si-si Hu Xiu-xiu Hou Xin Zhu Jun Cao Lie-hao Jiang Ming-hua Ge |
| author_sort | Jin-lin Hu |
| collection | DOAJ |
| description | ATM and γH2AX play a vital role in the detection of DNA double-strand breaks (DSB) and DNA damage response (DDR). This study aims to investigate ATM and γH2AX expression in thyroid cancer and discuss possible relationship between thyroid function tests and DNA damage. The expression of ATM and γH2AX was detected by immunohistochemistry in 30 cases of benign nodular goiter, 110 cases of well differentiated thyroid cancer, 22 cases of poorly differentiated thyroid cancer, and 21 cases of anaplastic thyroid cancer. Clinicopathological features, including differentiation stages, distant metastasis, lymph node metastasis, T classification, TNM stage, and tests of thyroid functions (TPOAb, Tg Ab, T3, FT3, T4, FT4, TSH, and Tg), were reviewed and their associations with γH2AX and ATM were analyzed. γH2AX and ATM expressed higher in thyroid cancer tissues than in benign nodular goiter and normal adjacent tissues. γH2AX was correlated with ATM in thyroid cancer. Both γH2AX and ATM expression were associated with FT3. γH2AX was also associated with T classification, TNM stage, FT4, TSH, and differentiation status. Therefore both of ATM and γH2AX seem to correlate with thyroid hormones and γH2AX plays a role in the differentiation status of thyroid cancer. |
| format | Article |
| id | doaj-art-c29be37872fa47629261e1dd965e2494 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c29be37872fa47629261e1dd965e24942025-02-03T05:53:24ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/136810136810Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid CarcinomaJin-lin Hu0Si-si Hu1Xiu-xiu Hou2Xin Zhu3Jun Cao4Lie-hao Jiang5Ming-hua Ge6Department of Pathology, Zhejiang Province Cancer Hospital, Hangzhou 310022, ChinaEmergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, ChinaZhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, ChinaZhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, ChinaZhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, ChinaZhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, ChinaDepartment of Head and Neck Surgery, Zhejiang Province Cancer Hospital, Hangzhou 310022, ChinaATM and γH2AX play a vital role in the detection of DNA double-strand breaks (DSB) and DNA damage response (DDR). This study aims to investigate ATM and γH2AX expression in thyroid cancer and discuss possible relationship between thyroid function tests and DNA damage. The expression of ATM and γH2AX was detected by immunohistochemistry in 30 cases of benign nodular goiter, 110 cases of well differentiated thyroid cancer, 22 cases of poorly differentiated thyroid cancer, and 21 cases of anaplastic thyroid cancer. Clinicopathological features, including differentiation stages, distant metastasis, lymph node metastasis, T classification, TNM stage, and tests of thyroid functions (TPOAb, Tg Ab, T3, FT3, T4, FT4, TSH, and Tg), were reviewed and their associations with γH2AX and ATM were analyzed. γH2AX and ATM expressed higher in thyroid cancer tissues than in benign nodular goiter and normal adjacent tissues. γH2AX was correlated with ATM in thyroid cancer. Both γH2AX and ATM expression were associated with FT3. γH2AX was also associated with T classification, TNM stage, FT4, TSH, and differentiation status. Therefore both of ATM and γH2AX seem to correlate with thyroid hormones and γH2AX plays a role in the differentiation status of thyroid cancer.http://dx.doi.org/10.1155/2015/136810 |
| spellingShingle | Jin-lin Hu Si-si Hu Xiu-xiu Hou Xin Zhu Jun Cao Lie-hao Jiang Ming-hua Ge Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma International Journal of Endocrinology |
| title | Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma |
| title_full | Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma |
| title_fullStr | Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma |
| title_full_unstemmed | Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma |
| title_short | Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma |
| title_sort | abnormal expression of dna double strand breaks related genes atm and gammah2ax in thyroid carcinoma |
| url | http://dx.doi.org/10.1155/2015/136810 |
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