Cortical morphological alterations in adolescents with major depression and non-suicidal self-injury
Background: Non-suicidal self-injury (NSSI) involves repetitive self-harm without suicidal intent and is common among adolescents, often linked to major depressive disorder (MDD). NSSI can lead to physical harm, cognitive impairments, interpersonal issues, violent behavior, and increased risks of ps...
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Elsevier
2024-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158224001426 |
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| author | Xiaonan Pang Dongpeng Wu Hongping Wang Jiahua Zhang Yue Yu Yue Zhao Qianqian Li Liangping Ni Kai Wang Dai Zhang Yanghua Tian |
| author_facet | Xiaonan Pang Dongpeng Wu Hongping Wang Jiahua Zhang Yue Yu Yue Zhao Qianqian Li Liangping Ni Kai Wang Dai Zhang Yanghua Tian |
| author_sort | Xiaonan Pang |
| collection | DOAJ |
| description | Background: Non-suicidal self-injury (NSSI) involves repetitive self-harm without suicidal intent and is common among adolescents, often linked to major depressive disorder (MDD). NSSI can lead to physical harm, cognitive impairments, interpersonal issues, violent behavior, and increased risks of psychological disorders and suicide attempts later in life. Methods: Voxel-based morphometry (VBM) and surface-based morphometry (SBM) were performed on 44 NSSI patients and 44 healthy controls (HCs). Differences in GMV, CT, and cortical complexity were compared using the two-sample t-tests and correlated with neuropsychological scales. Results: NSSI patients exhibited significant GMV atrophy in multiple regions, including the left insula, left anterior cingulate cortex, left putamen, left middle frontal gyrus, and right superior frontal gyrus showing increased GMV in the cerebellum posterior lobe. NSSI patients had increased CT in multiple left hemisphere regions and decreased CT in the right middle frontal gyrus. Additionally, they exhibited reduced cortical complexity, including decreased SD in the right frontal gyrus, and lower GI in the left insula. There were no significant differences between the two groups in terms of fractal dimension (FD). NSSI patients showed negative correlation between the CT of the right middle frontal gyrus and the anger dimension of the BPAQ, as well as the SD of the right superior frontal gyrus and the hostility dimension of the BPAQ. Conclusion: NSSI patients have significant structural changes in the insular cortex, prefrontal cortex, precentral and postcentral gyrus, temporal lobe, putamen, and anterior cingulate cortex, offering a morphological perspective on the pathophysiology of NSSI in MDD. |
| format | Article |
| id | doaj-art-c27d4e7f1ee641388a57e9124dc97ef7 |
| institution | Kabale University |
| issn | 2213-1582 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj-art-c27d4e7f1ee641388a57e9124dc97ef72024-11-29T06:23:46ZengElsevierNeuroImage: Clinical2213-15822024-01-0144103701Cortical morphological alterations in adolescents with major depression and non-suicidal self-injuryXiaonan Pang0Dongpeng Wu1Hongping Wang2Jiahua Zhang3Yue Yu4Yue Zhao5Qianqian Li6Liangping Ni7Kai Wang8Dai Zhang9Yanghua Tian10Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Anhui Province, Hefei 230022, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Anhui Province, Hefei 230022, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, ChinaThe College of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230022, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Anhui Province, Hefei 230022, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Anhui Province, Hefei 230022, ChinaDepartment of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, ChinaDepartment of Radiology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Anhui Province, Hefei 230022, China; The College of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230022, ChinaDepartment of Radiology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Corresponding authors at: Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China (Y. Tian).Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Department of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Anhui Province, Hefei 230022, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Corresponding authors at: Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China (Y. Tian).Background: Non-suicidal self-injury (NSSI) involves repetitive self-harm without suicidal intent and is common among adolescents, often linked to major depressive disorder (MDD). NSSI can lead to physical harm, cognitive impairments, interpersonal issues, violent behavior, and increased risks of psychological disorders and suicide attempts later in life. Methods: Voxel-based morphometry (VBM) and surface-based morphometry (SBM) were performed on 44 NSSI patients and 44 healthy controls (HCs). Differences in GMV, CT, and cortical complexity were compared using the two-sample t-tests and correlated with neuropsychological scales. Results: NSSI patients exhibited significant GMV atrophy in multiple regions, including the left insula, left anterior cingulate cortex, left putamen, left middle frontal gyrus, and right superior frontal gyrus showing increased GMV in the cerebellum posterior lobe. NSSI patients had increased CT in multiple left hemisphere regions and decreased CT in the right middle frontal gyrus. Additionally, they exhibited reduced cortical complexity, including decreased SD in the right frontal gyrus, and lower GI in the left insula. There were no significant differences between the two groups in terms of fractal dimension (FD). NSSI patients showed negative correlation between the CT of the right middle frontal gyrus and the anger dimension of the BPAQ, as well as the SD of the right superior frontal gyrus and the hostility dimension of the BPAQ. Conclusion: NSSI patients have significant structural changes in the insular cortex, prefrontal cortex, precentral and postcentral gyrus, temporal lobe, putamen, and anterior cingulate cortex, offering a morphological perspective on the pathophysiology of NSSI in MDD.http://www.sciencedirect.com/science/article/pii/S2213158224001426Non-suicidal self-injuryMajor depressive disorderStructural magnetic resonance imagingSurface-based morphometryVoxel-based morphometry |
| spellingShingle | Xiaonan Pang Dongpeng Wu Hongping Wang Jiahua Zhang Yue Yu Yue Zhao Qianqian Li Liangping Ni Kai Wang Dai Zhang Yanghua Tian Cortical morphological alterations in adolescents with major depression and non-suicidal self-injury NeuroImage: Clinical Non-suicidal self-injury Major depressive disorder Structural magnetic resonance imaging Surface-based morphometry Voxel-based morphometry |
| title | Cortical morphological alterations in adolescents with major depression and non-suicidal self-injury |
| title_full | Cortical morphological alterations in adolescents with major depression and non-suicidal self-injury |
| title_fullStr | Cortical morphological alterations in adolescents with major depression and non-suicidal self-injury |
| title_full_unstemmed | Cortical morphological alterations in adolescents with major depression and non-suicidal self-injury |
| title_short | Cortical morphological alterations in adolescents with major depression and non-suicidal self-injury |
| title_sort | cortical morphological alterations in adolescents with major depression and non suicidal self injury |
| topic | Non-suicidal self-injury Major depressive disorder Structural magnetic resonance imaging Surface-based morphometry Voxel-based morphometry |
| url | http://www.sciencedirect.com/science/article/pii/S2213158224001426 |
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