Eosinophilic solid and cystic renal cell carcinoma: a case study of the youngest surgical patient
Abstract Background Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a rare subtype of renal cell carcinoma. The tumor often presents without specific clinical symptoms or detectable signs for a definitive diagnosis. The vast majority of ESC RCC are sporadic, with a few associated wit...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-08-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-03300-w |
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| Summary: | Abstract Background Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a rare subtype of renal cell carcinoma. The tumor often presents without specific clinical symptoms or detectable signs for a definitive diagnosis. The vast majority of ESC RCC are sporadic, with a few associated with tuberous sclerosis. This case report details a young patient diagnosed with ESC RCC. We recommend complete excision of the tumor after a comprehensive evaluation, followed by postoperative pathology, to achieve a conclusive diagnosis. Case summary An 8-year-old boy was incidentally found to have multifocal renal masses in the right kidney during routine physical examination one year ago, without presenting abdominal pain or hematuria. Contrast-enhanced abdominal computed tomography (CT) revealed two isodense masses (27 × 21 mm and 20 × 16 mm) at the upper pole of the right kidney. PET imaging showed no signs of metastasis. The patient underwent robot-assisted partial nephrectomy, and postoperative pathological examination diagnosed ESC RCC. Genetic testing showed no significant abnormalities. After 8 months of follow-up, there were no signs of recurrence or metastasis. This ESC RCC case is likely the youngest case reported to date in urological oncology records, according to current data. Conclusion A combination of imaging studies and postoperative pathological examination is crucial for the definitive diagnosis of rare tumors. For small renal tumors with well-defined borders, no evidence of metastasis, and no tumor thrombus, robot-assisted laparoscopic partial nephrectomy is a viable treatment option for pediatric renal tumors. The pathogenesis of ESC RCC requires further investigation with more data. |
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| ISSN: | 2730-6011 |