One-step introduction of the hexafluoroisobutyl group, synthesis of (S)-5,5,5,5',5',5'-hexafluoroleucine, and its incorporation into peptides and proteins

One-step introduction of the hexafluoroisobutyl group, synthesis of (S)-5,5,5,5',5',5'-hexafluoroleucine, and its incorporation into peptides and proteins

The isobutyl motif is a highly prevalent functional group in medicinal chemistry, commonly present in numerous drugs and bioactive compounds. In biological systems, it notably corresponds to the side chain of the amino acid leucine. The replacement of this branched chain by the hexafluoroisobutyl gr...

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Bibliographic Details
Main Authors: Delamare, Aline, Naulet, Guillaume, Mummadi, Sandeep, Guichard, Gilles, Compain, Guillaume
Format: Article
Language:English
Published: Académie des sciences 2024-12-01
Series:Comptes Rendus. Chimie
Subjects:
Fluoroalkylation
S<sub>N</sub>2' mechanism
Hydrofluorination
Hexafluoroleucine
Fluorinated peptide
Fluorinated protein
Online Access:https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.362/
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