Clinical Pharmacokinetics of Paraaminosalicylic Acid Tablets
Pharmacokinetic parameters of PAS-Akri coated tablets (Akrikhin, Russia) were investigated. The tablets contain paraaminosalicylic acid (PAS) as sodium dihydrate in an amount of 1000 mg. The single oral dose of the drug for healthy volunteers in the trial was 6, 9 or 12 tablets. In 7 days the dosage...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/200 |
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| author | I. I. Miroshnichenko G. B. Sokolova L. V. Mokhireva |
| author_facet | I. I. Miroshnichenko G. B. Sokolova L. V. Mokhireva |
| author_sort | I. I. Miroshnichenko |
| collection | DOAJ |
| description | Pharmacokinetic parameters of PAS-Akri coated tablets (Akrikhin, Russia) were investigated. The tablets contain paraaminosalicylic acid (PAS) as sodium dihydrate in an amount of 1000 mg. The single oral dose of the drug for healthy volunteers in the trial was 6, 9 or 12 tablets. In 7 days the dosage was changed. The blood samples were collected 0.25, 0.5, 0.75, 1, 2, 4, 6, 8 and 10 hours after the drug administration. The PAS serum levels were determined with HPLC. The trials will allow to optimize the dosing of PAS for providing efficient antituberculosis therapy. |
| format | Article |
| id | doaj-art-c25439f002384ee7b22a9bb6f6a7fcee |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-c25439f002384ee7b22a9bb6f6a7fcee2025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01541-22024199Clinical Pharmacokinetics of Paraaminosalicylic Acid TabletsI. I. Miroshnichenko0G. B. Sokolova1L. V. Mokhireva2Scientific Centre of Mental Health, Russian Academy of Medical Sciences, Moscow; Research Institute of Phthisiology and Pulmonologyry, I.M. Sechenov Moscow Medical Academy, Moscow; Akrikhin Co., MoscowScientific Centre of Mental Health, Russian Academy of Medical Sciences, Moscow; Research Institute of Phthisiology and Pulmonologyry, I.M. Sechenov Moscow Medical Academy, Moscow; Akrikhin Co., MoscowScientific Centre of Mental Health, Russian Academy of Medical Sciences, Moscow; Research Institute of Phthisiology and Pulmonologyry, I.M. Sechenov Moscow Medical Academy, Moscow; Akrikhin Co., MoscowPharmacokinetic parameters of PAS-Akri coated tablets (Akrikhin, Russia) were investigated. The tablets contain paraaminosalicylic acid (PAS) as sodium dihydrate in an amount of 1000 mg. The single oral dose of the drug for healthy volunteers in the trial was 6, 9 or 12 tablets. In 7 days the dosage was changed. The blood samples were collected 0.25, 0.5, 0.75, 1, 2, 4, 6, 8 and 10 hours after the drug administration. The PAS serum levels were determined with HPLC. The trials will allow to optimize the dosing of PAS for providing efficient antituberculosis therapy.https://www.antibiotics-chemotherapy.ru/jour/article/view/200clinical pharmacokineticsantituberculosis drugsparaaminosalicylic acidvolunteers |
| spellingShingle | I. I. Miroshnichenko G. B. Sokolova L. V. Mokhireva Clinical Pharmacokinetics of Paraaminosalicylic Acid Tablets Антибиотики и Химиотерапия clinical pharmacokinetics antituberculosis drugs paraaminosalicylic acid volunteers |
| title | Clinical Pharmacokinetics of Paraaminosalicylic Acid Tablets |
| title_full | Clinical Pharmacokinetics of Paraaminosalicylic Acid Tablets |
| title_fullStr | Clinical Pharmacokinetics of Paraaminosalicylic Acid Tablets |
| title_full_unstemmed | Clinical Pharmacokinetics of Paraaminosalicylic Acid Tablets |
| title_short | Clinical Pharmacokinetics of Paraaminosalicylic Acid Tablets |
| title_sort | clinical pharmacokinetics of paraaminosalicylic acid tablets |
| topic | clinical pharmacokinetics antituberculosis drugs paraaminosalicylic acid volunteers |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/200 |
| work_keys_str_mv | AT iimiroshnichenko clinicalpharmacokineticsofparaaminosalicylicacidtablets AT gbsokolova clinicalpharmacokineticsofparaaminosalicylicacidtablets AT lvmokhireva clinicalpharmacokineticsofparaaminosalicylicacidtablets |