Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone

Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone

Abstract Background Klebsiella pneumoniae is one of the most prevalent pathogens responsible for multiple infections in healthcare settings and the community. K. pneumoniae CG147, primarily including ST147 (the founder ST), ST273, and ST392, is one of the most globally successful MDR clone linked to...

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Bibliographic Details
Main Authors: Jianping Jiang, Astrid V. Cienfuegos-Galletd, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth, Liang Chen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Genome Medicine
Subjects:
Klebsiella pneumoniae
CG147
CRISPR-Cas
Anti-CRISPR
Genomic epidemiology
Online Access:https://doi.org/10.1186/s13073-025-01428-6
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