The J-shape of β2GPI reveals a cryptic discontinuous epitope across domains I and II

The J-shape of β2GPI reveals a cryptic discontinuous epitope across domains I and II

Beta-2-Glycoprotein I is the main target for pathogenic antiphospholipid syndrome autoantibodies. It can adopt several conformations, including an O-shape and two more linear J- and S-shapes. The in vivo existence of the O-shape is debated, and doubt remains pertaining to the pathogenic impact of ea...

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Bibliographic Details
Main Authors: C.J. Lalaurie, M. Kulke, N. Geist, M. Delcea, P.A. Dalby, T.C.R. McDonnell
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Journal of Structural Biology: X
Subjects:
Structural biology
Molecular Dynamics
Auto-antigen epitope
APS
Beta-2-glycoprotein I
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152425000169
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