A preregistered meta-meta-analysis on the global distribution of Hepatotropic Viruses
Introduction. Hepatotropic viruses (HAV, HBV, HCV, HDV, and HEV) significantly impact global health, with varying prevalence across regions. Objective. This study aims to systematically consolidate data from diverse meta-analyses to provide a contemporary reference on virus distribution and preva...
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| Format: | Article |
| Language: | English |
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Central Research Institute for Epidemiology
2024-11-01
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| Series: | Вопросы вирусологии |
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| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/16639/923 |
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| author | Shuaibu Suleiman Adeiza Md. Aminul Islam Hauwa’u Umar Mungadi Abdulmalik Bello Shuaibu Ranjit Sah |
| author_facet | Shuaibu Suleiman Adeiza Md. Aminul Islam Hauwa’u Umar Mungadi Abdulmalik Bello Shuaibu Ranjit Sah |
| author_sort | Shuaibu Suleiman Adeiza |
| collection | DOAJ |
| description | Introduction. Hepatotropic viruses (HAV, HBV, HCV, HDV, and HEV) significantly impact global health, with varying prevalence across regions.
Objective. This study aims to systematically consolidate data from diverse meta-analyses to provide a contemporary reference on virus distribution and prevalence.
Materials and methods. Adhering to PRISMA guidelines, the study utilized a mixed effects model for data integration. Quality evaluation was carried out with QUOROM and AMSTAR tools, with heterogeneity assessed via the Higgins I2 statistic, Q-statistic and Tau squared (τ2) values.
Results. The study analyzed 86 meta-analyses from 56 studies (2017–2022) with minimal overlap. Prevalence rates by region were as follows: MENA – 29.2%, Afghanistan – 9.14%, Africa – 8.10%. Prevalence rates by virus type: HAV – 82.5%, HBV – 8.6%, HCV – 15.1%, HDV – 8.9%, HEV – 13.9%, dual HBV-HCV coinfection – 2.2%. Prevalence rates by risk groups: general population – 8.3%, healthcare workers – 4.0%. Continent-specific HBV-HCV prevalence rates: Africa – 9.2%, China – 6.9%, others. HCVprevalence rates among at-risk groups: healthcare workers – 5.58%, hemodialysis patients – 34.8%. Regional HCV rates: Africa – 7.42%, Middle East – 25.30%.
Conclusion. Diverse global hepatotropic virus prevalence patterns are influenced by multifaceted factors. MENA faces higher rates due to healthcare challenges, while Africa struggles with limited resources. Tailored public health strategies, including vaccination and awareness campaigns, are essential to alleviate burdens and enhance global health. This consolidated data serves as a valuable resource for informed decision-making. |
| format | Article |
| id | doaj-art-c213cf8c4f684568b4198742d9fa9ed8 |
| institution | Kabale University |
| issn | 0507-4088 2411-2097 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj-art-c213cf8c4f684568b4198742d9fa9ed82024-11-12T12:34:23ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972024-11-0169542944010.36233/0507-4088-2341244A preregistered meta-meta-analysis on the global distribution of Hepatotropic VirusesShuaibu Suleiman Adeiza0https://orcid.org/0000-0002-9293-2600Md. Aminul Islam1https://orcid.org/0000-0003-1091-9726Hauwa’u Umar Mungadi2https://orcid.org/0000-0001-7200-1035Abdulmalik Bello Shuaibu3https://orcid.org/0000-0001-7684-2472Ranjit Sah4https://orcid.org/0000-0002-2695-8714Ahmadu Bello UniversityPresident Abdul Hamid Medical CollegeUsmanu DanFodiyo UniversityUsmanu DanFodiyo UniversityInstitute of MedicineIntroduction. Hepatotropic viruses (HAV, HBV, HCV, HDV, and HEV) significantly impact global health, with varying prevalence across regions. Objective. This study aims to systematically consolidate data from diverse meta-analyses to provide a contemporary reference on virus distribution and prevalence. Materials and methods. Adhering to PRISMA guidelines, the study utilized a mixed effects model for data integration. Quality evaluation was carried out with QUOROM and AMSTAR tools, with heterogeneity assessed via the Higgins I2 statistic, Q-statistic and Tau squared (τ2) values. Results. The study analyzed 86 meta-analyses from 56 studies (2017–2022) with minimal overlap. Prevalence rates by region were as follows: MENA – 29.2%, Afghanistan – 9.14%, Africa – 8.10%. Prevalence rates by virus type: HAV – 82.5%, HBV – 8.6%, HCV – 15.1%, HDV – 8.9%, HEV – 13.9%, dual HBV-HCV coinfection – 2.2%. Prevalence rates by risk groups: general population – 8.3%, healthcare workers – 4.0%. Continent-specific HBV-HCV prevalence rates: Africa – 9.2%, China – 6.9%, others. HCVprevalence rates among at-risk groups: healthcare workers – 5.58%, hemodialysis patients – 34.8%. Regional HCV rates: Africa – 7.42%, Middle East – 25.30%. Conclusion. Diverse global hepatotropic virus prevalence patterns are influenced by multifaceted factors. MENA faces higher rates due to healthcare challenges, while Africa struggles with limited resources. Tailored public health strategies, including vaccination and awareness campaigns, are essential to alleviate burdens and enhance global health. This consolidated data serves as a valuable resource for informed decision-making.https://virusjour.crie.ru/jour/article/viewFile/16639/923hepatitishepatotropic virusesmeta-analyseshavhbvhcvhdvhev |
| spellingShingle | Shuaibu Suleiman Adeiza Md. Aminul Islam Hauwa’u Umar Mungadi Abdulmalik Bello Shuaibu Ranjit Sah A preregistered meta-meta-analysis on the global distribution of Hepatotropic Viruses Вопросы вирусологии hepatitis hepatotropic viruses meta-analyses hav hbv hcv hdv hev |
| title | A preregistered meta-meta-analysis on the global distribution of Hepatotropic Viruses |
| title_full | A preregistered meta-meta-analysis on the global distribution of Hepatotropic Viruses |
| title_fullStr | A preregistered meta-meta-analysis on the global distribution of Hepatotropic Viruses |
| title_full_unstemmed | A preregistered meta-meta-analysis on the global distribution of Hepatotropic Viruses |
| title_short | A preregistered meta-meta-analysis on the global distribution of Hepatotropic Viruses |
| title_sort | preregistered meta meta analysis on the global distribution of hepatotropic viruses |
| topic | hepatitis hepatotropic viruses meta-analyses hav hbv hcv hdv hev |
| url | https://virusjour.crie.ru/jour/article/viewFile/16639/923 |
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