Examining genotype-phenotype associations of GRAM domain proteins using GWAS, PheWAS and literature review in cattle, human, pig, mouse and chicken

Examining genotype-phenotype associations of GRAM domain proteins using GWAS, PheWAS and literature review in cattle, human, pig, mouse and chicken

Abstract The GRAMD genes are involved in maintaining cholesterol homeostasis, apoptosis, cancer and production traits in livestock. A lipid-binding GRAM domain is implicated in lipid transport and metabolism. The functions of GRAMD proteins remain incompletely understood. The aim of the present stud...

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Bibliographic Details
Main Authors: Tanja Kunej, Martin Šimon, Barbara Luštrek, Simon Horvat, Klemen Potočnik
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Cattle
GRAM domain
GWAS
PheWAS
Single nucleotide polymorphism (SNP)
Mouse
Online Access:https://doi.org/10.1038/s41598-024-80117-7
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