Mitochondrial dysfunction mediated by ER-calcium dysregulation in neurons derived from Alzheimer’s disease patients

Mitochondrial dysfunction mediated by ER-calcium dysregulation in neurons derived from Alzheimer’s disease patients

Abstract Tight regulation of mitochondrial Ca2+ is essential for neuronal bioenergetics and cellular metabolism. Ca2+ transfer from ER-localized ryanodine receptors (RyR) and inositol triphosphate receptors (IP3R) to the mitochondria maintains a steady Ca2+ source that fuels oxidative phosphorylatio...

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Bibliographic Details
Main Authors: Sarah Mustaly-Kalimi, Wacey Gallegos, Daniel Steinbrenner, Smriti Gupta, Aiden J. Houcek, David A. Bennett, Robert A. Marr, Daniel A. Peterson, Israel Sekler, Grace E. Stutzmann
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Mitochondria
Calcium dysregulation
Ryanodine receptor
iPSC-derived neurons
Online Access:https://doi.org/10.1186/s40478-025-02023-x
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https://doi.org/10.1186/s40478-025-02023-x

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