HMGB1 Box A gene therapy to alleviate bleomycin-induced pulmonary fibrosis in rats

HMGB1 Box A gene therapy to alleviate bleomycin-induced pulmonary fibrosis in rats

Abstract Background Pulmonary fibrosis is characterized by the destruction of normal lung tissue and then replacement by abnormal fibrous tissue, leading to an overall decrease in gas exchange function. The effective treatment for pulmonary fibrosis remains unknown. The upstream pathogenesis of pulm...

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Bibliographic Details
Main Authors: Rathasapa Patarat, Suchanart Chuaybudda, Sakawdaurn Yasom, Apiwat Mutirangura
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Pulmonary Medicine
Subjects:
Idiopathic pulmonary fibrosis
DNA damage
DNA stability
DNA protection
Box a of HMGB1
Youth-DNA-gap
Online Access:https://doi.org/10.1186/s12890-025-03522-2
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