Cas12f1 gene drives propagate efficiently in herpesviruses and induce minimal resistance

Cas12f1 gene drives propagate efficiently in herpesviruses and induce minimal resistance

Abstract Background Synthetic CRISPR-Cas9 gene drive has been developed to control harmful species. However, resistance to Cas9 gene drive can be acquired easily when DNA repair mechanisms patch up the genetic insults introduced by Cas9 and incorporate mutations to the sgRNA target. Although many st...

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Bibliographic Details
Main Authors: Zhuangjie Lin, Qiaorui Yao, Keyuan Lai, Kehua Jiao, Xianying Zeng, Guanxiong Lei, Tongwen Zhang, Hongsheng Dai
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Biology
Subjects:
Gene drive
Cas12f1
Cas9
HSV1
Online Access:https://doi.org/10.1186/s13059-024-03455-9
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